Evidence map›Paper›PMID 41730764›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Breastmilk and medium-chain triglyceride supplementation: Retrospective study on outcomes in biliary atresia infants after Kasai.

Thora Wesenberg Helt, Ruben H de Kleine, Lars Søndergaard Johansen, Tietie Dijkstra, Jan B F Hulscher, Henkjan J Verkade, Vibeke Brix Christensen

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In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Thora Wesenberg HeltDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark.ORCID https://orcid.org/0000-0002-3763-8839
Ruben H de KleineDepartment of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Lars Søndergaard JohansenDepartment of Paediatric Surgery, Copenhagen University Hospital, Rigshospitalet, Denmark.
Tietie DijkstraDepartment of Pediatrics, Section of Dietetics, University Medical Center Groningen, Groningen, The Netherlands.
Jan B F HulscherDepartment of Surgery, Section of Pediatric Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Henkjan J VerkadeDepartment of Pediatrics, Section of Hepatology and Gastroenterology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Vibeke Brix ChristensenDepartment of Paediatric Surgery, Copenhagen University Hospital, Rigshospitalet, Denmark.

Funding

Charlotte Anderson Travel AwardDet Sundhedsvidenskabelige Fakultet, Københavns UniversitetKnud Højgaards FondThe John and Birthe Meyer Foundation
6 · The paper itself

Abstract

objectiveTo relate post-surgical feeding regimens to growth and surgical outcomes in children with biliary atresia (BA) after hepato-portoenterostomy (Kasai).

methodsRetrospectively, all children with BA from Denmark and the Netherlands who underwent Kasai from 2014 to 2022 were included. The effect of breastmilk intake on anthropometry after Kasai was evaluated using jointed modeling of longitudinal and survival data, removing children from the analysis at transplantation. Mixed linear models were used to assess surgical outcomes in relation to breastmilk intake and anthropometry in relation to medium-chain triglycerides (MCT) intake, adjusted for calorie intake.

resultsWe included 116 children. After Kasai, breastmilk with MCT supplementation was received in 22% for at least 1 month, 9% for 1 week, and 68% did not receive breastmilk. Those receiving breastmilk after Kasai had stable length-for-age z-score (LAZ) over 12 months whereas LAZ decreased in infants without breastmilk feeding (-0.48; 95% confidence interval [CI] 0.24, 0.72). Infants receiving breastmilk for at least 1 month had lower total bilirubin at 3 months (79 vs. 116 µmol/L, p = 0.028) and a lower incidence of cholangitis compared with infants not receiving breastmilk after Kasai. Of those only receiving formula after Kasai, 4% received <40% MCT, 72% received 40-59% MCT and 24% received ≥60% MCT. LAZ was lower in children with MCT intake <40% than in children with MCT intake ≥40%.

conclusionFeeding regimens in children with BA after Kasai are related to growth and surgical outcomes. Further studies with infants randomized to receive breast milk and to different MCT levels are needed.

Indexed as

Biliary AtresiaDietary SupplementsMilk, HumanPortoenterostomy, HepaticTriglyceridesBilirubinDenmarkFemaleHumansInfantMaleNetherlandsRetrospective StudiesTreatment OutcomeBilirubinTriglyceridesanthropometrybreastfeedingfeeding methods after Kasaipediatric liver disease

Identifiers

PMID41730764
PMCPMC13150791

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.