Evidence map›Paper›PMID 41730795›Full record

ReviewPharmacotherapy2026

Maternal and Pediatric Precision in Therapeutic Knowledge Portal (MPRINT-KP): Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations.

Xiaofu Liu, Aditi Shendre, Lei Wang, Aislinn O'Kane, Hanson Ma, Chien-Wei Chiang, Syed S Zaidi, Omar A Aboshady, Gerald So, Emma M Tillman and 23 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Xiaofu LiuDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-5721-091X
Aditi ShendreDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4123-7613
Lei WangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-1904-1737
Aislinn O'KaneDivision of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Hanson MaDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0005-0355-8119
Chien-Wei ChiangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-0988-8478
Syed S ZaidiDivision of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Omar A AboshadyDepartment of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-1505-3175
Gerald SoDivision of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0003-2101-5116
Emma M TillmanDivision of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0001-8019-9811
Lindsey M KirkpatrickDivision of Clinical Pharmacology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Maged CostantineDivision of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-4076-469X
Shaun GrannisDepartment of Family Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0002-8093-6639
Colin M RogersonDepartment of Pediatrics, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
Christopher BartlettDepartment of Pediatric, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-7837-6348
Saurabh RahurkarDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-8597-3087
Lijun ChengDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Jiayi OuyangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0008-9618-8226
Ping WeiDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0004-4256-5728
Zhimo ZhuDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0002-4651-7825
Shangjia LiDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0007-9620-935X
Yirui HuangCollege of Pharmacy, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0002-7639-0730
Lingling WangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-8997-9929
Weidan CaoDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-5417-2121
Haoran JiangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Jianing LiuDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Samuel-Richard OtengDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Andrew GoodwinDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Jiezel Ann Faith DeypalubosDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Shijun ZhangDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-4780-8416
Robert BiesDepartment of Pharmaceutical Science, School of Pharmacy and Pharmaceutical Science, University of Buffalo, Buffalo, New York, USA.ORCID 0000-0003-3818-2252
Sara K QuinneyDepartment of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0002-6554-0695
Lang LiDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-0746-1809

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUM1TR004548 · NCATS · OHIO STATE UNIVERSITY · PI CYNTHIA A GERHARDT, JULIE A. JOHNSON · 2023 to 2026
$22.0M
Indiana University Comprehensive Training in Clinical PharmacologyT32GM008425 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Zeruesenay Desta, Michael Thomas Eadon · 1992 to 2026
$7.7M
Machine learning drives translational research from drug interactions to pharmacogeneticsR01LM014199 · NLM · OHIO STATE UNIVERSITY · PI You Chen, Lang Li · 2023 to 2026
$2.5M
An informatics bridge over the valley of death for cancer Phase I trials of drug-combination therapiesU01CA248240 · NCI · OHIO STATE UNIVERSITY · PI LI, LANG · 2021 to 2023
$1.1M
Eunice Kennedy Shriver National Institute of Child Health and Human Development P30HD106451NCATS NIH HHS UM1TR004548NCI NIH HHS K12HD111057-03NCI NIH HHS U01CA248240NIGMS NIH HHS T32GM008425NLM NIH HHS R01LM014199
6 · The paper itself

Abstract

Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations. Maternal and Pediatric PRecision In Therapeutics Knowledge Portal (MPRINT-KP) is designed to provide a comprehensive view of pharmacokinetic, pharmaco-epidemiology, and clinical trial research evidence in maternal and pediatric patient populations. MPRINT-KP Silver was generated upon BioBERT models, due to their supreme performance in classifying pharmacokinetic, pharmaco-epidemiology, and clinical trial papers from PubMed, with an F1-score > 0.91. As of April 1, 2025, MPRINT-KP Silver contains 758,560 clinical pharmacology research papers in maternal and pediatric populations. The landscape analysis revealed a large number of drugs with pharmacology knowledge gaps, which is calculated as the relative frequency of drugs with no or weak (i.e., less than five publications) evidence in each of pharmacokinetic, pharmaco-epidemiology, or clinical trial study type. The highest pharmacotherapy knowledge gaps are in postpartum women, pregnant women, and pediatric patients between 0-12 and 12-18 years of age (51.37%, 32.47%, 25.82%, 32.11%, respectively). Pharmacovigilance analyses were conducted on highly prescribed drugs with limited pharmacology evidence in pediatric patients 0-2 year old and pregnant women using United States Food and Drug Administration Adverse Event Reporting System (FAERS) and MarketScan claims data. A number of new drug-associated adverse drug events (ADEs) were discovered. In pediatric patients, there were crisaborole-associated hemorrhage and moxifloxacin-associated cardiac toxicities. In pregnant women, the analysis revealed terconazole-associated abnormalities of heartbeat; benzonatate-associated depressive and anxiety disorders; buspirone-associated abnormalities of heartbeat; cyclobenzaprine-associated tubulo-interstitial nephritis; and pantoprazole-associated hearing loss and voice and resonance disorders. For the first time, a large-scale landscape analysis of pharmacotherapy knowledge gap in both maternal and pediatric patient populations was conducted and identified new drug associated ADE evidence using real world data.

Indexed as

Precision MedicineChildChild, PreschoolClinical Trials as TopicFemaleHumansInfantInfant, NewbornPharmacology, ClinicalPregnancyartificial intelligenceclinical trials as topicknowledge basesmaternal‐child nursingpharmacoepidemiologypharmacokineticstherapeutics

Identifiers

PMID41730795
PMCPMC12929201

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.