ArticleNature communications2026
Sono-mechanical nanostructures-enabled sustained precise ultrasound brain stimulation.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound can enable deep brain neuromodulation with high spatiotemporal resolution, comparable to well-known modalities like TMS, tDCS, and tACS. However, conventional transcranial ultrasound still lacks the precision needed to modulate a small set of neurons. Here, we introduce hollow silica nanostructures (HSN) that localize and amplify ultrasonic effects for long-term neuromodulation in male mice brains (>9 weeks) by activating mechanosensitive ion channels. By controlling the HSN amount and delivery site, ultrasound can selectively activate targeted brain regions, including M1, striatum, VTA, and STN, at time points ranging from days to weeks, and relieve PD motor symptoms in mice models, without evident toxicity. Overall, our stimulation approach offers a safe, minimally-invasive strategy for effective chronic neuromodulation without genetic modification, with notable therapeutic applications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.