Evidence map›Paper›PMID 41731197›Full record

ReviewArchives of pharmacal research2026

Neuroinflammation and blood-brain barrier disruption in Japanese encephalitis virus infection: mechanisms, therapeutic targets, and intervention strategies.

Xiaochun Ye, Ping Wang, Mengping Song, Jieying Zhang, Xiangmin Li, Xu Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of pharmacal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaochun YeNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
Ping WangNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
Mengping SongNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
Jieying ZhangNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China.
Xiangmin LiCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. lixiangmin@mail.hzau.edu.cn.
Xu WangNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. wangxu@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0001-6476-0509

Funding

National Key Research and Development Program of China 2023YFD1800801the National Natural Science Foundation of China grant numbers 32373046
6 · The paper itself

Abstract

Japanese encephalitis virus (JEV), as a neurotropic flavivirus, remains a primary cause of viral encephalitis and poses a significant public health challenge. Its pathogenic mechanism centers on the pathological interaction between blood-brain barrier (BBB) disruption and uncontrolled neuroinflammation, which collectively promote JEV neuroinvasion and result in irreversible brain damage. Therefore, elucidating the molecular mechanisms by which JEV disrupts the BBB and induces neuroinflammation is crucial for developing novel therapeutic strategies. This paper systematically elucidates the mechanisms by which JEV induces BBB disruption and neuroinflammation, focusing on key viral and host factors. Furthermore, we summarize recent advances in innate immune responses during JEV infection and explore potential therapeutic strategies to alleviate neuroinflammation and restore BBB integrity. Finally, we explored key knowledge gaps, translational medicine challenges, and future research directions. Given the current lack of specific antiviral treatments, there is an urgent need to develop novel intervention approaches to improve clinical outcomes.

Indexed as

Antiviral AgentsBlood-Brain BarrierEncephalitis, JapaneseEncephalitis Virus, JapaneseNeuroinflammatory DiseasesAnimalsHumansAntiviral AgentsAntiviral responseAntiviralsBlood–brain barrierCentral nervous systemJapanese encephalitis virusNeuroinflammationTargets

Identifiers

PMID41731197

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.