Evidence map›Paper›PMID 41731693›Full record

ReviewTumori2026

Choriocarcinoma: Diagnosis, treatment and management of a rare germ cell tumour. An update review.

Pierantoni Francesco, Fabiana Caliciotti, Selma Ahcene Djaballah, Eleonora Lai, Davide Bimbatti, Silvia Stragliotto, Ilaria Zampiva, Melissa Ballestrin, Chiara Pittarello, Salim Jubran and 5 more

Erratum issuedAbstract readReview
In one paragraph

Review in Tumori, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Constructing anTranslational cancer research · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Pierantoni FrancescoOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0000-0002-8483-0196
Fabiana CaliciottiOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.
Selma Ahcene DjaballahOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0000-0002-3878-3595
Eleonora LaiOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0000-0001-7726-1864
Davide BimbattiOncology 1 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.
Silvia StragliottoOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.
Ilaria ZampivaOncology 1 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0000-0003-4858-3965
Melissa BallestrinOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0009-0003-3167-0525
Chiara PittarelloDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.
Salim JubranDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.ORCID 0009-0003-7406-5544
Greta PrettoOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0009-0007-4448-9716
Elisa ErbettaDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.
Anna MilaniOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.
Umberto BassoOncology 1 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.ORCID 0000-0002-5075-2177
Marco MaruzzoOncology 3 Unit, Istituto Oncologico Veneto, IOV - IRCCS, Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Choriocarcinoma is a malignant neoplasia which develops from trophoblastic cells. In males it is rare and often associated with other non-seminomatous germ cell tumours of the testis. Choriocarcinoma often presents with metastatic disease and elevated βHCG levels. Usually, patients' symptoms are associated with the different metastatic sites and they can be severe or even life-threatening. Moreover, choriocarcinoma is chemosensitive and the administration of chemotherapy with curative intent may lead to tumour-lysis syndrome and the more specific choriocarcinoma syndrome (CS). Therefore, the treatment of metastatic choriocarcinoma is complex, involving both oncological therapy and the management of acute complications. This review explores choriocarcinoma in males, focusing on its clinical presentation, pathogenetic mechanisms, and treatment options, including investigational therapies. Additionally, we aim to highlight the severe complications of CS and discuss its management strategies.

Indexed as

ChoriocarcinomaNeoplasms, Germ Cell and EmbryonalTesticular NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsHumansMalechoriocarcinomaGCTgerm cell tumoursnon-seminomatous germ cell tumoursNSGCT

Identifiers

PMID41731693
PMCPMC13250271

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.