Association between relative fat mass and increased prevalence of gallstone disease in American adults: A cross-sectional study.

The aim of this study was to investigate the relationship between relative fat mass (RFM) and the occurrence of gallstone disease (GSD) among American adults. A total of 15,560 adults were included. RFM, body mass index (BMI) and WC were taken into account. The receiver operating characteristic curve was utilized. Logistic regression and restricted cubic spline were employed to examine the potential correlation between RFM and the incidence of GSD. A cohort of 7515 individuals with GSD was studied. RFM, BMI, and WC were significantly associated with an elevated incidence of GSD in women in the unadjusted and adjusted models. Specifically, for every 1 standard deviation (SD) increase in BMI, WC, and RFM, the odds of GSD increased by 69%, 71%, and 77% in women. Notably, RFM had a higher area under the curve value compared to BMI in women. Among women, the prevalence of GSD was associated with a higher prevalence among individuals in the highest RFM tertile than in the lowest tertile (OR = 3.08, 95% confidence interval: 2.13-4.47, P < .001). The application of restricted cubic spline regression demonstrated a linear relationship between RFM and the likelihood of GSD. Higher RFM is positively associated with a higher prevalence of GSD in American women. Compared to BMI, RFM demonstrates a stronger association with GSD and may serve as a more useful anthropometric indicator in this population.