Evidence map›Paper›PMID 41732122›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Waking up to the truth: Associations between sleep disorders and multidomain functional outcomes in Alzheimer's disease.

Chao Tang, Jiaxin Yang, Yi Chen, Xiaoxue Peng, Xiaoyang Lei, Ming Zhang, Dian He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chao TangDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Jiaxin YangDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Yi ChenDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Xiaoxue PengDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Xiaoyang LeiDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Ming ZhangDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.
Dian HeDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.ORCID https://orcid.org/0000-0003-0550-6249

Funding

National Alzheimer's Coordinating CenterU24AG072122 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$9.3M
Research EducationP30AG062421 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$4.8M
Research Education Component (REC)P30AG066530 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$4.8M
Yale Alzheimer Disease Research CenterP30AG066508 · YALE UNIVERSITY · 2025 to 2025
$4.8M
Research Education CoreP30AG066462 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$4.8M
REC CoreP30AG066514 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$4.7M
Research Education ComponentP30AG062422 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$4.7M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$4.6M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$4.6M
Research Education ComponentP30AG066468 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$4.5M
Research Education ComponentP30AG062677 · MAYO CLINIC ROCHESTER · 2025 to 2025
$4.5M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · EMORY UNIVERSITY · 2025 to 2025
$4.5M
National Institute on Aging and National Institutes of Health P30 AG079280NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS U24 AG072122STI2023-Major Projects 2021ZD0201801The Guizhou Provincial Clinical Medical Research Center Construction Project - Neurological Disease Research LCZX[2025]003The Guizhou Provincial Science and Technology Support Program Project 2025-117The Key and Dominant Discipline Construction Project of the Health Commission of Guizhou Province in 2023, China
6 · The paper itself

Abstract

introductionSleep disorders are common in older adults and have been increasingly linked to cognitive dysfunction in Alzheimer's disease (AD); however, their associations with functional outcomes and underlying pathways remain insufficiently characterized.

methodsWe performed a cross-sectional analysis of 10,823 participants from the National Alzheimer's Coordinating Center database, examining associations between sleep disorders and instrumental activities of daily living (IADL) using regression, structural equation modeling (SEM), and mediation analyses.

resultsSleep disorders were significantly associated with greater cognitive impairment and poorer IADL performance among individuals with AD. Mediation analysis indicated that cognitive impairment accounted for ≈62% of the association between sleep disorders and IADL difficulties, suggesting a substantial indirect association through cognitive function. DISCUSSION: Sleep disorders are strongly associated with cognitive impairment and functional limitations in AD. These findings highlight the potential clinical value of screening and managing sleep problems as part of comprehensive care strategies.

Indexed as

Activities of Daily LivingAlzheimer DiseaseCognitive DysfunctionSleep Wake DisordersAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleNeuropsychological TestsAlzheimer's diseasecognitive impairmentmultidomain functional impairmentssleep disordersstructural equation modeling

Identifiers

PMID41732122
PMCPMC12930103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.