Evidence map›Paper›PMID 41732312›Full record

ArticleAmerican heart journal plus : cardiology research and practice2026

The role of Id genes on pulmonary hypertension development in left heart failure.

Christelle Lteif, Paula Wachs, Ravindra K Sharma, Julio D Duarte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christelle LteifCenter for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL, USA.
Paula WachsCenter for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL, USA.
Ravindra K SharmaDivision of Nephrology, Hypertension and Renal Transplantation, Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Julio D DuarteCenter for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the role of Design: Experimental study using an AKR/J mouse model of HF-PH and a genetic association study using the UK Biobank cohort. Setting: Laboratory animal study and population-based cohort study. Participants: AKR/J mice with HF-PH and participants with HF from the UK Biobank cohort. Interventions: Administration of tacrolimus (Id signaling inducer) in the mouse model. Main outcome measures: Tissue-specific gene expression of Results: Conclusion: The results suggest

Indexed as

Gene expressionHeart failureInhibitors of DNA-bindingPulmonary hypertensionSingle nucleotide polymorphismsTacrolimusUK Biobank

Identifiers

PMID41732312
PMCPMC12925738

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.