ArticleCureus2026
Dry Age-Related Macular Degeneration and Dense Deposit Disease: A Histopathological Comparison of Macular and Renal Lesions.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Dry age-related macular degeneration (AMD) and dense deposit disease (DDD) in the kidney have molecular commonality due to the involvement of the complement system. DDD is a renal disease linked to defects of the complement alternative pathway, and in dry AMD, complement components have been found within drusen. In this study, pathologic features of dry AMD and DDD were studied by light and immunofluorescence microscopy to clarify whether morphologic similarities exist between the two diseases. Methodology Sections were obtained from (1) the macula of four patients with dry AMD; (2) renal biopsies of two DDD patients; (3) the macula from healthy eye donors; and (4) a kidney biopsy of a normal human subject. Sections were stained with hematoxylin and eosin, periodic acid-Schiff (PAS), and periodic-acid-methenamine silver for light microscopy and with C3b antisera for fluorescence microscopy. Results Changes observed in dry AMD specimens included (1) the presence of numerous drusen containing PAS- and silver-positive material; (2) thickening of the Bruch's membrane; (3) thickening of prominent PAS-positive intercapillary pillars; and (4) degeneration and dropouts in the choriocapillaris and dilatation and congestion of vessels in the Sattler's layer. In comparison, changes in the DDD specimens included (1) thickening of the glomerular basement membrane (GBM) and presence of double contours; and (2) mesangial and endocapillary proliferation. C3b was positive in both macular drusen and along the GBM. Conclusions Basement membrane changes in dry AMD share morphological similarities with the GBM changes in DDD, and, in both diseases, C3b is deposited, suggesting that the association between the two diseases possibly reflects a common pathogenesis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.