Evidence map›Paper›PMID 41732744›Full record

ArticleJID innovations : skin science from molecules to population health2026

The 4E-BP1 deletion modestly mitigates mTORC1-deficient epidermal barrier defects.

Huihao Tang, Mengyu Jin, Ruyan Li, Hanyu Dou, Jianzhou Li, Juan Wang, Sabine A Eming, Xiaolei Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huihao TangInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Mengyu JinInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Ruyan LiInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Hanyu DouInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Jianzhou LiInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Juan WangInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Sabine A EmingDepartment of Dermatology, University of Cologne, Cologne, Germany.
Xiaolei DingInstitute of Geriatrics, Nantong Hospital (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

mTOR signaling is essential for epidermal development, yet the downstream mechanisms mediating its effects remain unclear. The 4E-BP1 (eukaryotic initiation factor 4E-binding protein 1), a major mTORC1 target that inhibits cap-dependent translation, has an undefined role in epidermal morphogenesis. In this study, we investigated the impact of 4E-BP1 loss on mTORC1 inactivation-mediated skin barrier defects.

Indexed as

4E-BP1EpidermismTORSkin barrier

Identifiers

PMID41732744
PMCPMC12925558

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.