Evidence map›Paper›PMID 41732803›Full record

ArticleAnnals of clinical and translational neurology2026

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease.

Deborah A Hall, Kimberly Kwei, Rolando J Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L Purcell, Natasha Desai and 7 more

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In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Deborah A HallDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-2772-7851
Kimberly KweiDepartment of Neurology, Movement Disorders, Columbia University Medical Center, New York, New York, USA.
Rolando J AcostaRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Bharatkumar KoyaniRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Erin RobertsonRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Pratyush RaiRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.ORCID https://orcid.org/0000-0001-6525-5782
Roland BargeRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.ORCID https://orcid.org/0009-0006-9762-4769
Emily TimmDepartment of Anatomy & Cell Biology, Rush University Medical Center, Chicago, Illinois, USA.
Nicollette L PurcellIllinois College of Optometry, Chicago, Illinois, USA.
Natasha DesaiDepartment of Neurology, Movement Disorders, Columbia University Medical Center, New York, New York, USA.
Dhanesh PatelRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Ana-Maria Visoiu-KnappRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Samuel StuartRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Rinol AlajRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
Matthew F WippermanRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.ORCID https://orcid.org/0000-0003-1436-3366
Oren LevyRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.ORCID https://orcid.org/0000-0002-9146-821X
Joan A O'KeefeDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

Funding

Regeneron Pharmaceuticals
6 · The paper itself

Abstract

objectiveGait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease.

methodsA comparative analysis between digital insoles (Moticon ReGo Insole) and the GAITRite system was conducted in patients with Parkinson's disease. Patients were assessed in both the OFF and ON medication states. Gait characteristics were measured simultaneously with both systems during two 10 m walk tests. Patients also completed a patient experience survey following the use of the digital insoles.

resultsOverall, 21 patients with Parkinson's disease were included in the study. Analytical validation for gait cadence, speed, and stride length showed excellent agreement (intraclass correlation coefficients between 0.93-0.97) in both the OFF and ON states. Stance, swing, and double support times exhibited lower validity with moderate agreement (intraclass correlation coefficients from 0.48-0.57). Gait speed and stride length were significantly associated with scores on the Movement Disorders Society's Unified Parkinson's Disease Rating Scale (p = 0.0085 and 0.013, respectively). Mean differences in all parameters measured with the insoles, except cadence, were significantly different between OFF and ON states (p < 0.003). The majority of patients liked wearing the digital insoles and found them comfortable and user-friendly.

interpretationThese findings support the validity of Moticon ReGo digital insoles for the assessment of several important gait characteristics in Parkinson's disease.

Indexed as

digital insoleParkinson's diseasewearables

Identifiers

PMID41732803
PMCPMC13394956

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.