Evidence map›Paper›PMID 41733083›Full record

ReviewACS infectious diseases2026

Antimicrobial Peptides in Preventive Medicine: Current Perspectives on Coating Strategies.

Milan Wouters, Laurence Van Moll, Emine Derin, Sara Van Looy, Linda De Vooght, Peter Delputte, Paul Cos

Abstract readReview
In one paragraph

Review in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Milan WoutersLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.ORCID 0009-0000-2741-9299
Laurence Van MollLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.
Emine DerinLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.
Sara Van LooyLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.ORCID 0009-0001-8060-6437
Linda De VooghtLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.
Peter DelputteLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.
Paul CosLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Antwerp 2000, Belgium.ORCID 0000-0003-4361-8911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alarming rise of antimicrobial resistance and the declining efficacy of conventional antibiotics emphasize the need for preventive strategies. Within the setting of device-associated infections, antimicrobial peptides (AMPs) have been extensively studied as antimicrobial candidates, owing to their broad-spectrum activity and structural versatility, enabling integration into functional surface coatings. This review provides a comprehensive overview of AMP-based prophylactic approaches, with a particular focus on coatings for medical devices prone to biofilm formation, such as endotracheal tubes, catheters and implants. While surface immobilization of peptides can be accomplished through comparatively straightforward methodologies, the field has progressed toward sophisticated matrix-based systems that enhance stability, biocompatibility and controlled functionality. Yet, despite extensive in vitro and small-scale in vivo studies, clinical translation remains very limited and constrained by several hurdles including regulatory ambiguity and production costs. Overall, this work aims to provide an up-to-date overview of the AMP-based technologies in infection prevention research.

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesCoated Materials, BiocompatiblePreventive MedicineAnimalsBiofilmsHumansAnti-Bacterial AgentsAntimicrobial PeptidesCoated Materials, Biocompatibleantibacterial coatingsantimicrobial peptidesdevice-associated infectionspreventive medicine

Identifiers

PMID41733083
PMCPMC13006958

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.