Evidence map›Paper›PMID 41733157›Full record

ArticleJournal of natural products2026

Genetic Dereplication of Multiple

Mira Syahfriena Amir Rawa, Benjamin J Haefner, Grant R Nickles, Enrique Aguilar-Ramírez, Nancy P Keller, Justin L Eagan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mira Syahfriena Amir RawaDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-1916-0154
Benjamin J HaefnerDepartment of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-6793-9368
Grant R NicklesDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Enrique Aguilar-RamírezDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-4386-9473
Justin L EaganDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-1679-6117

Funding

Comprehensive analysis of NRPS-derived metabolomes of three Aspergillus speciesR01GM112739 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2015 to 2023
$2.8M
Accessing the hidden biosynthetic capabilities of fungiR35GM156119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI NANCY P KELLER · 2025 to 2026
$923k
NIGMS NIH HHS R01 GM112739NIGMS NIH HHS R35 GM156119
6 · The paper itself

Abstract

Genetic dereplication by targeted deletion of major secondary metabolite biosynthetic pathways is an effective strategy to uncover novel compounds and cryptic biosynthetic gene clusters (BGCs). In this study, we engineered a "flatline" strain of

Indexed as

Multigene FamilyPenicilliumPeptides, CyclicBiosynthetic PathwaysCitrininHeterocyclic Compounds, 4 or More RingsIndolesMolecular StructurePatulinPeptide SynthasesPipecolic AcidsPiperazinesCitrininHeterocyclic Compounds, 4 or More RingsIndolesnon-ribosomal peptide synthasePatulinPeptides, CyclicPeptide Synthasespipecolic acidPipecolic AcidsPiperazinesroquefortine

Identifiers

PMID41733157
PMCPMC13036780

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.