Evidence map›Paper›PMID 41733233›Full record

Observational studyClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Respiratory Syncytial Virus Hospitalizations in Adults ≥50 Years of Age and Those With Congestive Heart Failure or Chronic Obstructive Pulmonary Disease Exacerbations, 2018-2020.

Ashley Tippett, Pragati V Prasad, Elizabeth Begier, Sara S Kim, Theda Gibson, Luis W Salazar, Meg Taylor, Olivia Reese, Gabby Ess, Chris Choi and 24 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Ashley TippettDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-1791-2677
Pragati V PrasadRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
Elizabeth BegierPfizer, Inc, New York City, New York, USA.ORCID 0000-0002-1287-5416
Sara S KimRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-1056-9896
Theda GibsonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Luis W SalazarDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-5454-5741
Meg TaylorDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Olivia ReeseDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Gabby EssDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Chris ChoiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Caroline CiricDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Elizabeth Grace TaylorDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0000-2453-8137
Khalel De CastroDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Samadhan JadhaoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
HeYing SunDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0009-0008-6466-6430
Hui-Mien HsiaoDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Shadwal GuptaDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Wensheng LiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Kathleen StephensDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Robin HublerPfizer, Inc, New York City, New York, USA.
Qing LiuPfizer, Inc, New York City, New York, USA.
David SwerdlowPfizer, Inc, New York City, New York, USA.
Bradford D GessnerPfizer, Inc, New York City, New York, USA.
Sonal UppalPfizer, Inc, New York City, New York, USA.
Caihua LiangPfizer, Inc, New York City, New York, USA.
Warren KalinaPfizer, Inc, New York City, New York, USA.
Luis JodarPfizer, Inc, New York City, New York, USA.ORCID 0000-0003-1246-530X
Satoshi KamidaniDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-6829-0700
Inci YildirimDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA.
Nadine RouphaelDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-2512-7919
Kristin N NelsonRollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-4728-2909
Larry J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-0652-6834
Christina A RostadDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-8439-0592
Evan J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.

Funding

Pfizer Inc
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a leading cause of acute respiratory illness (ARI) in older adults and those with comorbidities. Understanding disease burden could guide prevention efforts.

methodsWe performed active surveillance for RSV among adults aged ≥50 years hospitalized with ARI and adults of any age hospitalized with congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD) exacerbations from Georgia Health District 3 at 2 Atlanta hospitals during 2 respiratory seasons (2018-2019 and 2019-2020). All participants were tested for RSV using the BioFire Respiratory Panel (nasopharyngeal and oropharyngeal swabs); subsets also had serology and standard-of-care results. Annual population-based incidences of RSV-related hospitalizations were estimated by age strata and study group, adjusting for differences in sampling, diagnostic testing, and test sensitivity. Denominators for ARI incidence estimates were from the US Census. CHF and COPD denominators were limited to individuals with underlying CHF or COPD, respectively, as defined by NHANES data.

resultsOf 3090 eligible patients, 1558 were included; 757 (48.6%) had ARI, 490 (31.4%) CHF exacerbation, and 311 (20.0%) COPD exacerbation. Overall, 92 (5.9%) participants tested positive for RSV. Based on data from 2 seasons, annual population-based incidences among adults aged ≥50 years were 74 per 100 000 (95% confidence interval [CI]: 73, 77) for laboratory-confirmed RSV-related ARI hospitalizations alone, and 58% higher when including all laboratory-confirmed RSV-related hospitalizations (ARI and CHF/COPD exacerbations): 117 per 100 000 (95% CI: 114, 123).

conclusionsRSV was associated with a substantial burden of hospitalizations among adults aged ≥50 years, particularly when CHF and COPD exacerbations were included.

Indexed as

Heart FailureHospitalizationPulmonary Disease, Chronic ObstructiveRespiratory Syncytial Virus InfectionsAgedAged, 80 and overDisease ProgressionFemaleGeorgiaHumansIncidenceMaleMiddle AgedProspective StudiesRespiratory Syncytial Virus, HumanCHFCOPDincidenceolder adultsRSV

Identifiers

PMID41733233
PMCPMC13537122

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.