Evidence map›Paper›PMID 41733252›Full record

ReviewClinical and translational gastroenterology2026

Targeting the Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.

Yaning Fang, Ruoheng Wang, Xinyu Du, Zheye Ying, Yi Yang, Yuxiang Cheng, Ziteng Pan, Xiwen Lu, Jing Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yaning FangSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ruoheng WangDepartment of Chemoradiotherapy, Ningbo NO.2 Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.
Xinyu DuSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Zheye YingSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yi YangSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.ORCID 0009-0008-0908-792
Yuxiang ChengSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ziteng PanSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xiwen LuNingbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, China .ORCID 0000-0002-8074-6667
Jing ZhouDepartment of Chemoradiotherapy, Ningbo NO.2 Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China.ORCID 0009-0008-2746-2199

Funding

Huamei Foundation of Ningbo No.2 Hospital No.2024HMKYA02Innovation Training Program for College Students of Zhejiang Province No.S202513023023Ningbo Yongjiang Talent programme-Project for Innovative Talents No.2024034
6 · The paper itself

Abstract

The increasing global burden of digestive diseases, coupled with the complexity of their pathogenesis, underscores the urgent need for in-depth research into precise organ-specific therapies. The Cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase-stimulator of interferon genes pathway, a crucial innate immune signaling axis, has garnered considerable attention for its roles in immune defense, inflammation regulation, tumorigenesis, and tissue homeostasis. In this review, we outline common digestive diseases linked to the Cyclic GMP-AMP synthase-stimulator of interferon genes pathway, elucidate its mechanistic contributions to these conditions, and provide a detailed analysis of how targeting this signaling axis may influence disease progression. We hope this review will offer a theoretical foundation for developing novel therapeutics and innovative treatment strategies for digestive diseases, thereby contributing to improved clinical outcomes.

Indexed as

Membrane ProteinsNucleotidyltransferasesSignal TransductionAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHost-Directed TherapyHumansImmunity, InnateMolecular Targeted TherapySTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteincGAS-STINGdigestive system diseaseeffective treatment strategiesMolecular mechanism

Identifiers

PMID41733252
PMCPMC13193311

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.