Evidence map›Paper›PMID 41733284›Full record

ArticleJACC. Basic to translational science2026

OPA1 Deficiency Impairs NGF Signaling and Drives Sympathetic Neurodegeneration.

Marco Ronfini, Valentina Prando, Vittoria Di Mauro, Lolita Dokshokova, Erika Lazzeri, Irene Costantini, Lukas Alàn, Erwan Andre Riviere, Alex Incensi, Camilla Olianti and 8 more

Abstract read
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In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marco RonfiniDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy.
Valentina PrandoDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy.
Vittoria Di MauroDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy.
Lolita DokshokovaDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy.
Erika LazzeriEuropean Laboratory for Non-linear Spectroscopy, University of Florence, Florence, Italy.
Irene CostantiniEuropean Laboratory for Non-linear Spectroscopy, University of Florence, Florence, Italy; National Institute of Optics, National Research Council, University of Florence, Florence, Italy; Department of Biology, University of Florence, Italy.
Lukas AlànVeneto Institute of Molecular Medicine, Padova, Italy; Department of Biology, University of Padova, Italy.
Erwan Andre RiviereVeneto Institute of Molecular Medicine, Padova, Italy; Department of Biology, University of Padova, Italy.
Alex IncensiIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Camilla OliantiEuropean Laboratory for Non-linear Spectroscopy, University of Florence, Florence, Italy.
Chiara La MorgiaIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Rocco LiguoriIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Leonardo SacconiInstitute of Clinical Physiology, National Research Council, Florence, Italy; Institute for Experimental Cardiovascular Medicine, University Heart Center and Medical Faculty, University of Freiburg, Freiburg, Germany.
Vincenzo DonadioIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Luca ScorranoVeneto Institute of Molecular Medicine, Padova, Italy; Department of Biology, University of Padova, Italy.
Valerio CarelliIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Marco MongilloDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy; CNR Institute of Neuroscience, Padova, Italy; Interdepartmental Research Center of Myology (cirMYO), Padova, Italy.
Tania ZagliaDepartment of Biomedical Sciences, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy; Interdepartmental Research Center of Myology (cirMYO), Padova, Italy. Electronic address: tania.zaglia@unipd.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral sympathetic neurodegeneration drives cardiac dysfunction in dominant optic atrophy, revealing a critical neuro-cardiac link. Optic atrophy factor-1 haploinsufficiency disrupts mitochondrial dynamics and neurotrophic signaling, causing targeted sympathetic denervation and arrhythmias. Restoring nerve growth factor transport and mitochondrial health in sympathetic neurons represents a promising therapeutic avenue for cardiac autonomic disorders. Future research must unravel mechanisms of neurocardiac crosstalk to develop precise interventions against neurogenic cardiac disease progression.

Indexed as

dominant optic atrophymitochondrianerve growth factoroptic atrophy factor-1sympathetic neurons

Identifiers

PMID41733284
PMCPMC12960036

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.