Evidence map›Paper›PMID 41733340›Full record

ArticleMicrobiology spectrum2026

XopA: a novel type III secretion system effector in

Xiyin Huang, Xingya Dong, Chen Li, Jiajie Xie, Yunjun Sun, Yibo Hu, Liqiu Xia, Qiang Tu, Youming Zhang, Shengbiao Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiyin HuangInstitute of Synthetic Biology Industry (College of Synthetic Biology Industry), Hunan University of Arts and Science, Changde, China.ORCID 0009-0006-5684-5530
Xingya DongInstitute of Synthetic Biology Industry (College of Synthetic Biology Industry), Hunan University of Arts and Science, Changde, China.
Chen LiState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha, China.
Jiajie XieState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha, China.
Yunjun SunState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha, China.
Yibo HuState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha, China.
Liqiu XiaState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha, China.
Qiang TuInstitute of Synthetic Biology Industry (College of Synthetic Biology Industry), Hunan University of Arts and Science, Changde, China.ORCID 0000-0002-8552-9485
Youming ZhangInstitute of Synthetic Biology Industry (College of Synthetic Biology Industry), Hunan University of Arts and Science, Changde, China.
Shengbiao HuState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Provincial Key Laboratory of Microbial Molecular Biology, College of Life Science, Hunan Normal University, Changsha, China.ORCID 0000-0001-9236-6496

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The type III secretion system (T3SS) of bacterial pathogens plays an essential role in infection and colonization processes. T3S effectors (T3SEs) are pivotal in mediating these interactions and their mechanisms of action. This study delves into the functional mechanisms of XopA, the first T3SE identified in the bacterium IMPORTANCE: This study reports the groundbreaking discovery of XopA as the first type III secretion system effectors (T3SE) identified in

Indexed as

ApoptosisAutophagyBacterial ProteinsImmune EvasionType III Secretion SystemsXenorhabdusAcetylationAnimalsHeLa CellsHost-Pathogen InteractionsHumansVirulence FactorsBacterial ProteinsType III Secretion SystemsVirulence Factorsacetylation modificationsapoptosis and autophagyentomopathogenic nematode symbiotic bacteriaT3SSYopJ family effectors

Identifiers

PMID41733340
PMCPMC13055249

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.