ReviewProgress in molecular and subcellular biology2026
Chronic Wound Healing: Breakthrough Strategies Based on Inorganic Polyphosphate.
Review in Progress in molecular and subcellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
Wound healing is a highly energy-dependent process. Physiologically, the required metabolic energy is supplied by the blood platelets in the form of inorganic polyphosphate, which serves as a source for the generation of the energy carrier adenosine triphosphate (ATP). However, due to metabolic diseases, circulatory disorders, or bacterial wound infections, this energy supply can be insufficient, leading to the development of chronic wounds that are difficult or impossible to treat with conventional methods. It has been shown that this energy deficiency can be remedied by the topical application of synthetic polyP and amorphous polyP nanoparticles that mimic the natural polymer. Initial studies on patients were successful, as summarized in this chapter. Amorphous calcium carbonate particles stabilized with polyP as a source of soluble calcium have proven to be another promising application form of the polymer alongside polyP and polyP nanoparticles.
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41733675What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.