Evidence map›Paper›PMID 41734139›Full record

ArticleGerontology2026

Population-Based Structural Evidence: Triadic Effects of Periodontitis, Depression, and Biological Aging on Cognitive Health.

Dawei Zhang, Shijie Zhu, Zhaobiao Zong, Lijian Jin, Patrick Rijkschroeff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dawei ZhangDivision of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong, China.
Shijie ZhuSchool of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, China.
Zhaobiao ZongCollege of Education, Huaibei Normal University, Huaibei, China.
Lijian JinDivision of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong, China.
Patrick RijkschroeffDivision of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong, China, prf660@hku.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Cognitive impairment represents critical public health challenges in aging societies. This study investigated periodontitis, depression, and biological aging's triadic effects on cognition.

methodsStructural equation modeling (SEM) and relative weight analysis (RWA) were applied to analyze data from 2011 to 2014 National Health and Nutrition Examination Survey (NHANES) (N = 1,816). Cognitive function, periodontitis, depression, and biological age (PhenoAge) were assessed with covariates adjustment.

resultsSEM revealed periodontitis severity, depressive symptoms, and PhenoAge advancement exhibited significant direct associations with lower cognitive performance after covariate adjustment. Simultaneously, biological aging partially mediated the influence of both depression and periodontitis on cognitive outcomes. RWA showed dominated cognitive variance, while periodontitis, depression, and PhenoAge contributed significantly.

conclusionThis supports triadic interdependencies where biological aging partially mediates the associations between periodontitis/depression and cognition. Prioritizing periodontal care and mental health may mitigate cognitive decline, especially in low-resource settings. </p>.

Indexed as

AgingCognitionCognitive DysfunctionDepressionPeriodontitisAgedFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesBiological ageCognitive impairmentDepressionPeriodontitis

Identifiers

PMID41734139
PMCPMC13075863

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.