In one paragraphArticle in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Julia EichermüllerDepartment of Nephrology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-0393-3856 Jessica FaberInstitute of Continuum Mechanics and Biomechanics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fürth, Germany.ORCID 0000-0001-8372-495X Camilla MussoniDepartment of Functional Materials in Medicine and Dentistry, Institute of Biofabrication and Functional Materials, University of Würzburg, Würzburg, Germany.ORCID 0009-0001-4878-4604 Julian BauerInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-2149-1094 Jonas RöderDepartment of Materials Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0009-0004-2321-6821 Alessandro CianciosiDepartment of Functional Materials in Medicine and Dentistry, Institute of Biofabrication and Functional Materials, University of Würzburg, Würzburg, Germany.ORCID 0009-0009-1314-4437 Philipp StahlhutDepartment of Functional Materials in Medicine and Dentistry, Institute of Biofabrication and Functional Materials, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-1874-1504 Tomasz JungstDepartment of Functional Materials in Medicine and Dentistry, Institute of Biofabrication and Functional Materials, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-2458-8713 Jürgen GrollDepartment of Functional Materials in Medicine and Dentistry, Institute of Biofabrication and Functional Materials, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-3167-8466 Dominik SteinerDepartment of Plastic and Hand Surgery, BG Clinic Tübingen, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-1904-5925 Oliver FriedrichInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0003-2238-2049 Taufiq AhmadDepartment of Functional Materials in Medicine and Dentistry, Institute of Biofabrication and Functional Materials, University of Würzburg, Würzburg, Germany.
Aldo R BoccacciniDepartment of Materials Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-7377-2955 Silvia BuddayInstitute of Continuum Mechanics and Biomechanics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fürth, Germany.ORCID 0000-0002-7072-8174 Janina Müller-DeileDepartment of Nephrology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-6081-5664 Funding
Deutsche Forschungsgemeinschaft 506565062Deutsche Forschungsgemeinschaft (DFG: German Research Foundation 506565062DFG 326998133 - TRR 225DFG A01DFG B09DFG C01DFG C06DFG Z02
6 · The paper itselfAbstract
Conventional 2D mono-cultures fall short in replicating the complex microenvironment of glomerular tissue, where cell-cell and cell-matrix interactions are critical. To better mimic in vivo conditions, the development of robust 3D co-culture systems is essential. Here, we systematically evaluate five hydrogel matrices-Matrigel, alginate dialdehyde-gelatin (ADA-GEL), fibrin, recombinantly produced spider silk protein eADF4(C16)-RGD, and allyl-modified gelatin (GelAGE)-for their suitability in supporting glomerular 3D co-culture. The hydrogels are assessed for handling properties, cell viability, and the support of physiological cell behavior using bright-field microscopy, live/dead assays, immunofluorescence, and multiphoton imaging. Among the tested hydrogels, GelAGE and eADF4(C16)-RGD demonstrate superior biocompatibility and structural support. Due to its ease of use and comparable biological performance, GelAGE and spider silk protein eADF(C16)-RGD are selected for further mechanical characterization, revealing favorable viscoelastic properties. These findings position both hydrogels as a promising candidate for engineering physiologically relevant 3D glomerular models and advancing kidney tissue research.
Indexed as
Biocompatible MaterialsCell Culture Techniques, Three DimensionalHydrogelsKidney GlomerulusMaterials TestingAlginatesAnimalsCell SurvivalCoculture TechniquesCollagenDrug CombinationsFibrinGelatinHumansLamininProteoglycansAlginatesBiocompatible MaterialsCollagenDrug CombinationsFibrinGelatinHydrogelsLamininmatrigelProteoglycansSilkADA‐GELfibrin gelGelAGEglomerular co‐culturematrigelspider silk
Identifiers
PMID41734260
PMCPMC12931831
What Socratic holds
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