Evidence mapPaperPMID 41734262Full record

Trial reportJournal of clinical psychology2026

Impact of the Unified Protocol on Attenuated Psychotic Symptoms, Cognitive Biases and Cognitive Insight in Patients at Ultra High Risk (UHR) for Psychosis: Secondary Results of a Pilot Randomized Controlled Trial.

Trinidad Peláez, Raquel López-Carrilero, Victoria Espinosa, Sol Balsells, Paolo Fusar-Poli, Susana Ochoa, Jorge Osma

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of clinical psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Trinidad PeláezParc Sanitari Sant Joan de Déu, Barcelona, Spain.ORCID https://orcid.org/0000-0002-5363-9778
Raquel López-CarrileroParc Sanitari Sant Joan de Déu, Barcelona, Spain.
Victoria EspinosaParc Sanitari Sant Joan de Déu, Barcelona, Spain.
Sol BalsellsFundació Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.
Paolo Fusar-PoliDepartment of Psychosis Studies, Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, King's College London, London, UK.ORCID https://orcid.org/0000-0003-3582-6788
Susana OchoaParc Sanitari Sant Joan de Déu, Barcelona, Spain.
Jorge OsmaDepartamento de Psicología y Sociología, Universidad de Zaragoza, Teruel, Spain.ORCID https://orcid.org/0000-0002-7293-318X

Funding

Gobierno de AragónParc Sanitari Sant Joan de Déu
6 · The paper itself

Abstract

background and hypothesisUltra high risk (UHR) for psychosis can have different clinical trajectories but the remission rates are only 51.9% after 3 years of follow-up. Deficits in metacognition are associated with severity of symptoms and poor response to treatment. We hypothesize that the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) will have a positive effect on attenuated psychotic symptoms, cognitive biases and cognitive insight in UHR individuals. STUDY

designThis article reports the secondary analyses of a pilot randomized controlled trial with 36 UHR participants assigned to either an online group intervention with UP plus Treatment as Usual (UP + TAU) or TAU alone. Assessments were conducted at baseline, post-intervention and 3-month follow-up and included the severity and distress of attenuated psychotic symptoms (CAARMS), cognitive biases (CBQp) and cognitive insight (BCIS). STUDY

resultsSignificant differences were found in the evolution of the two groups in CAARMS distress scores in favor of the UP condition group. Significant differences in CBQp scores between the two groups were found in the two time assessments in favor of the UP group. No significant differences were found in cognitive insight.

conclusionsThe UP intervention showed promising effects in reducing distress related to attenuated psychotic symptoms and cognitive biases, but not in improving cognitive insight. Given the small sample size, which fell below the initial target, and the pilot nature of the study, these findings should be interpreted with caution and considered preliminary until replicated in adequately powered trials.

Indexed as

Affective SymptomsMetacognitionOutcome Assessment, Health CarePsychotherapy, GroupPsychotic DisordersAdolescentAdultCognitive Behavioral TherapyFemaleHumansMalePilot ProjectsRiskYoung Adultattenuated psychotic symptomsMCTmetacognitionpsychotherapyUHR

Identifiers

PMID41734262
PMCPMC13127844

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.