Evidence map›Paper›PMID 41734995›Full record

ArticleJournal for immunotherapy of cancer2026

Macrophage

Yu Jiang, Lingyuan Min, Xinyu Yang, Fengguo Zhang, Quanye Sun, Yanxia Lin, Wenyu Zhang, Yuling Li, Guanglin Fu, Xiuxiu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu JiangDepartment of Clinical Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Lingyuan MinResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Xinyu YangResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Fengguo ZhangDepartment of Reproductive Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Quanye SunResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Yanxia LinResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Wenyu ZhangDepartment of Clinical Research Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Yuling LiDepartment of Gynecology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Guanglin FuDepartment of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.
Xiuxiu LiuResearch Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China liuxiuxiu19841001@163.com.ORCID http://orcid.org/0000-0002-7536-818X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMetadherin (MTDH) is a recognized oncogene involved in the progression and metastasis of various cancers. However, further studies are needed to elucidate the biological role of MTDH, which is expressed in macrophages during tumor progression.

methodsMouse colorectal cancer and melanoma cells were subcutaneously and intravenously injected into myeloid-specific

results

conclusionsWe found that macrophage

Indexed as

Lung NeoplasmsMacrophagesMembrane ProteinsRNA-Binding ProteinsThrombospondin 1AnimalsCell Line, TumorCell ProliferationHumansMiceMice, KnockoutNeoplasm MetastasisNeovascularization, PathologicTransforming Growth Factor beta1Membrane ProteinsMtdh protein, mouseRNA-Binding ProteinsThbs1 protein, mouseThrombospondin 1Transforming Growth Factor beta1Colorectal CancerCytokineExtracellular MatrixMacrophageSkin Cancer

Identifiers

PMID41734995
PMCPMC12933811

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.