Evidence map›Paper›PMID 41735242›Full record

ArticleNeurogastroenterology and motility2026

Percutaneous Electrical Nerve Field Stimulation Improves Weight and Other Anthropometric Outcomes in Children and Adolescents With Functional Dyspepsia Who Restrict Their Oral Intake.

Umber Waheed, Austin VonAxelson, Khalil El-Chammas, Kahleb Graham, Sherief Mansi, Jennifer Hardy, Megan M Miller, Rashmi Sahay, Neha R Santucci

Abstract read
In one paragraph

Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Umber WaheedPediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA.
Austin VonAxelsonPediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA.
Khalil El-ChammasPediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA.
Kahleb GrahamPediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA.
Sherief MansiPediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA.
Jennifer HardyGastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA.
Megan M MillerBehavioral Medicine and Clinical Psychology, CCHMC, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-6222-2659
Rashmi SahayBiostatistics, CCHMC, Cincinnati, Ohio, USA.
Neha R SantucciGastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA.

Funding

Disrupted sleep architecture in adolescents with functional abdominal pain disordersK23DK135797 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Neha Richard Santucci · 2023 to 2026
$765k
NIDDK NIH HHS K23 DK135797
6 · The paper itself

Abstract

backgroundFunctional dyspepsia (FD), a disorder of the gut-brain interaction (DGBI), can result in restricted eating habits with associated weight loss. Percutaneous Electrical Nerve Field Stimulation (PENFS), a minimally invasive non-pharmacologic approach, can improve abdominal pain and psychological functioning in children with DGBI. We aimed to analyze changes in anthropometric measures, nutritional intake, and clinical outcomes with PENFS.

methodsWe retrospectively reviewed charts of patients with FD (9-28 years) who restricted oral intake and underwent PENFS. We analyzed validated questionnaires used during treatment. Anthropometric data were also assessed during and after 3 months of treatment. Results were analyzed through linear mixed modeling as least square means. KEY

resultsNinety patients reported restricted oral intake, 42% had baseline weight loss and 13% requiring enteral support. Oral intake (p = 0.001), weight (p = 0.02) and BMI (p = 0.002) significantly increased after PENFS. Abdominal pain, nausea, functional disability, depression, and somatization also improved after PENFS. Increased weight Z scores were associated with lower nausea, pain catastrophizing, and depression. CONCLUSIONS AND INFERENCES: PENFS improved oral intake, weight, and other anthropometric measures in addition to GI and psychological measures in patients with FD. Changes in anthropometrics were sustained at 3-month follow up. PENFS may be an effective treatment for patients with FD, including children, and restrictive eating to optimize nutritional outcomes. Future studies should include prospective clinical trials and investigate the mechanism of action of PENFS on eating habits.

Indexed as

Body WeightDyspepsiaTranscutaneous Electric Nerve StimulationAbdominal PainAdolescentAdultAnthropometryChildFemaleHumansMaleRetrospective StudiesTreatment OutcomeWeight LossYoung Adultabdominal painfunctional dyspepsiarestricted eatingvagal neuromodulationweight loss

Identifiers

PMID41735242
PMCPMC13086553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.