Observational studyScientific reports2026
High-flow nasal-cannula oxygen therapy in intensive-care-unit patients: a prospective multicenter observational cohort study (OHE-REA).
Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04141956 (Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units : Prospective, Multi-center, Epidemiological, Uncontrolled Study
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0 citing papers in PubMed.
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-flow oxygen therapy (HFOT) has become the most common oxygen-supplementation modality in patients with acute respiratory failure, based chiefly on data from tightly selected patients included in randomized trials. Our objective was to obtain real-life data on HFOT failure. This prospective observational multicenter French study done in 13 intensive care units in 2019–2020 was designed to determine the proportion of patients with failed HFOT, defined as intubation, noninvasive ventilation, standard oxygen therapy with an estimated FiO2>50%. We included 257 patients before prematurely ending the study due to the COVID-19 pandemic. HFOT failed in 79 patients (32%), including 42 (17%) who required intubation. Mean HFOT duration was 2.4 ± 2.2 days. By multivariate analysis, a low ROX index (ratio of pulse-oximeter saturation (SpO2) over FiO2, over the respiratory rate (RR) was associated with HFOT failure (adjusted hazard ratio [aHR], 0.83; 95%CI, 0.77–0.90, P < 0.0001), as were elevated mean arterial pressure (aHR, 1.03; 95%CI, 1.02–1.05), vasopressor therapy (aHR, 3.35; 95%CI, 1.44–7.79), and worse Glasgow Coma Scale score (aHR, 0.69; 95%CI, 0.57–0.80, P < 0.001). The identification of factors independently associated with HFOT failure should help to determine which patients are most likely to benefit from HFOT, thereby preventing delayed intubation. Additional studies are needed to further assess these risk factors and to determine the optimal HFOT weaning modalities.Trial registration: The study was registered on the ClinicalTrials.gov registry on February 11, 2019 (NCT04141956).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.