Evidence map›Paper›PMID 41735532›Full record

ArticleNature immunology2026

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.

Sina Frischholz, Ev-Marie Schuster, Myriam Grotz, Christine Schülein, Julia Benz, Katharina Kocher, Lucia Klotz, Szilard Varga, Theresa Hiltner, Rayya Alsalameh and 14 more

Abstract read
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Sina Frischholz *Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0009-0004-9376-9309
Ev-Marie Schuster *Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-2469-9501
Myriam Grotz *Mikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Christine SchüleinMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Julia BenzMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Katharina KocherMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0003-2331-3838
Lucia KlotzMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Szilard VargaDepartment of Internal Medicine 5 - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Theresa HiltnerInstitute for Medical Microbiology, Immunology, and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Rayya AlsalamehMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Jan EsseMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Johannes TrägerMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Jürgen HeldMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Frederik GrawDepartment of Internal Medicine 5 - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0002-1198-6632
Jürgen PahleBiological Information Processing Group, BioQuant, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7637-7547
Bernd SpriewaldDepartment of Internal Medicine 5 - Hematology and Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Luca GattinoniDivision of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.ORCID http://orcid.org/0000-0003-2239-3282
Veit R BuchholzInstitute for Medical Microbiology, Immunology, and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Felix DrostInstitute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Benjamin SchubertInstitute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3412-1102
Simon RothenfußerInstitute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-1151-7614
Dirk H BuschInstitute for Medical Microbiology, Immunology, and Hygiene, School of Medicine and Health, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-8713-093X
Christian BogdanMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0002-2300-0631
Kilian SchoberMikrobiologisches Institut-Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. kilian.schober@uk-erlangen.de.ORCID http://orcid.org/0000-0001-9323-9472

Funding

Agence Nationale de la Recherche (French National Research Agency)) ANR-17-CE15-0031-01Boehringer Ingelheim Stiftung (Boehringer Ingelheim Foundation) RETENTIONDeutsche Forschungsgemeinschaft (German Research Foundation) 369799452Deutsche Forschungsgemeinschaft (German Research Foundation) 391217598Deutsche Forschungsgemeinschaft (German Research Foundation) 401821119Deutsche Forschungsgemeinschaft (German Research Foundation) 447268119Deutsche Forschungsgemeinschaft (German Research Foundation) BO996/7-1EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101137459EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 949719Else Kröner-Fresenius-Stiftung (Else Kroner-Fresenius Foundation) 2020_EKEA.127Klaus Tschira Stiftung (Klaus Tschira Foundation) 00.013.2019
6 · The paper itself

Abstract

Metabolic activity shapes cell fate but remains challenging to capture in vivo with high resolution. Here we performed longitudinal metabolic and phenotypic profiling of human antigen-specific CD8

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryMemory T CellsCell DifferentiationGlycolysisHumansMetabolic ReprogrammingOxidative PhosphorylationVaccinationYellow Fever VaccineYellow Fever Vaccine

Identifiers

PMID41735532
PMCPMC12956582

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.