ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Social determinants of health and stroke risk: A dose-response analysis of cumulative socioeconomic burden in US adults.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Social determinants of health and stroke care and outcomes: SEQUINS lecture 2025.Equity neuroscience · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is one of the leading causes of death and disability worldwide, with significant socioeconomic burdens. While traditional risk factors like hypertension are well-established, the role of social determinants of health (SDoH) in stroke risk remains understudied.
methodsWe conducted a cross-sectional analysis of 35,741 NHANES participants (2005-2018), including 1,502 stroke cases. Eight SDoH indicators were evaluated using survey-weighted multivariable logistic regression, with adjustments for demographic and clinical covariates. Stratified analyses examined sex, race, and age variations.
resultsSignificant associations were found between adverse SDoH and stroke risk: unemployment (adjusted odds ratio (AOR) = 2.37, 95%CI:1.98-2.85), low income (AOR = 1.71, 95%CI:1.42-2.06), food insecurity (AOR = 1.25, 95%CI:1.06-1.47), and housing instability (AOR = 1.36, 95%CI:1.18-1.57). A clear dose-response relationship was observed between cumulative SDoH burden and stroke risk. Compared to those with no adverse SDoH, individuals with 1, 2, 3, 4, and 5 adverse SDoH had progressively higher adjusted odds ratios of 1.76 (95%CI:1.36-2.26), 2.15 (1.67-2.77), 3.04 (2.35-3.94), 4.21 (3.28-5.40), and 9.66 (6.86-13.61), respectively (P for trend < 0.0001). Subgroup analyses revealed that the associations between adverse SDoH and stroke risk varied significantly by sex and race, but not by age groups.
conclusionThese findings demonstrate that SDoH independently and cumulatively influence stroke risk, with significant variations by sex and race. The results highlight the need for integrated prevention strategies addressing both medical risk factors and adverse SDoH, particularly for high-risk populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.