Evidence mapPaperPMID 41735549Full record

ReviewNature biotechnology2026

Agentic AI and the rise of in silico team science in biomedical research.

Binglan Li, Anil Kumar Saini, Jose Guadalupe Hernandez, Jason H Moore

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Synthetic nucleic acids in a post-agent biosecurity Era.Frontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Binglan Li *Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0103-6107
Anil Kumar Saini *Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9211-1079
Jose Guadalupe Hernandez *Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jason H MooreCedars-Sinai Medical Center, Los Angeles, CA, USA. jason.moore@csmc.edu.

Funding

Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · CEDARS-SINAI MEDICAL CENTER · 2025 to 2025
$1.6M
Resource Core 3 (RC3), Data ScienceP30AG094848 · CEDARS-SINAI MEDICAL CENTER · 2025 to 2025
$1.5M
Knowledge-guided automated machine learning methods for modeling the interaction of HIV with addictive drugsR01LM014572 · CEDARS-SINAI MEDICAL CENTER · 2025 to 2025
$491k
NIA NIH HHS P30 AG094848NIA NIH HHS U01 AG066833NLM NIH HHS R01 LM010098NLM NIH HHS R01 LM014572
6 · The paper itself

Abstract

Agentic artificial intelligence (AI) systems are emerging as teams of intelligent computational experts capable of rivaling human performance in labor-intensive tasks, including literature review, hypothesis formulation, data analysis and model interpretation. These systems are poised to accelerate labor-intensive biomedical research by making autonomous decisions based on contextual information and expert feedback. Agentic AI systems have been developed for various applications, including drug discovery, data analysis and biomarker identification; however, several distinct challenges remain for making these systems broadly deployable in biomedical research. Here we discuss three key algorithms and seven foundational building-block characteristics that contribute to the development of agentic AI systems. We highlight their biomedical applications, design considerations and the challenges and opportunities associated with deploying agentic AI systems to advance collaborative scientific research.

Indexed as

Artificial IntelligenceBiomedical ResearchComputer SimulationAlgorithmsDrug DiscoveryHumansIntelligent Systems

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.