Evidence mapPaperPMID 41735690Full record

ReviewPharmaceutical research2026

An Overview of Endometriosis and Potential Pharmacogenetic Targets.

Noelia Pérez-Gómez, María Ángeles Martínez-Zamora, Francisco Carmona, Jesús Novalbos, Francisco Abad-Santos, Dora Koller, Miriam Saiz-Rodríguez

Abstract readReview
In one paragraph

Review in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noelia Pérez-GómezResearch Unit, Fundación Burgos Por La Investigación de La Salud (FBIS), Hospital Universitario de Burgos, Burgos, 09006, Spain.
María Ángeles Martínez-ZamoraDepartment of Gynecology, Clinical Institute of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, University of Barcelona, Institut Clínic d´Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.
Francisco CarmonaDepartment of Gynecology, Clinical Institute of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, University of Barcelona, Institut Clínic d´Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Spain.
Jesús NovalbosClinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-Princesa), Madrid, 28006, Spain.
Francisco Abad-SantosClinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IIS-Princesa), Madrid, 28006, Spain.
Dora KollerDepartment of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, 08028, Spain.
Miriam Saiz-RodríguezResearch Unit, Fundación Burgos Por La Investigación de La Salud (FBIS), Hospital Universitario de Burgos, Burgos, 09006, Spain. miriamsr@ubu.es.ORCID http://orcid.org/0000-0002-1660-3135

Funding

Consejería de Educación, Junta de Castilla y León BU-103-25Fundació la Marató de TV3 PI049956Ministerio de Ciencia e Innovación RYC2024-050099-I
6 · The paper itself

Abstract

backgroundEndometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity. It affects approximately 10-15% of women of reproductive age globally and is characterized by heterogeneous symptoms with chronic pelvic pain, dysmenorrhea, and infertility being the most common. Although pharmacological treatments are available to manage its symptoms, many women either do not respond to these therapies or experience adverse drug reactions (ADRs) that outweigh the original symptoms of endometriosis. RATIONALE/

objectivesThe aim of this review is to provide a comprehensive overview of endometriosis and to identify pharmacogenetic markers that might influence drug response in its treatment and management. OUTCOMES: Current research highlights a critical gap in pharmacogenetic biomarkers for endometriosis treatment, limiting the potential for personalized therapeutic strategies. WIDER IMPLICATIONS: Integrative multi-omics approaches combining genetic, inflammatory, and hormonal profiles may enhance patient stratification and optimize individualized care.

Indexed as

EndometriosisPharmacogeneticsAnimalsFemaleHumansPrecision Medicinedrug responseendometriosispharmacogeneticsprecision medicine

Identifiers

PMID41735690
PMCPMC13076487

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.