Evidence map›Paper›PMID 41735694›Full record

ArticlePharmaceutical research2026

Estimating Human Jejunal Effective Permeability Using Numerical Deconvolution of Oral Solution Concentration Data.

Wenqian Zhang, Jia Geng, Xingrui He, Hanxi Yi, Jie Dong, Lin Mei, Feifan Xie

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Article in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenqian ZhangDivision of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University, Tongzipo Road 172, Changsha, 410013, China.
Jia GengDivision of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University, Tongzipo Road 172, Changsha, 410013, China.
Xingrui HeDivision of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University, Tongzipo Road 172, Changsha, 410013, China.
Hanxi YiDepartment of Pathology, School of Basic Medical Science, Central South University, Changsha, China.
Jie DongDepartment of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Lin MeiState Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Feifan XieDivision of Biopharmaceutics and Pharmacokinetics, Xiangya School of Pharmaceutical Sciences, Central South University, Tongzipo Road 172, Changsha, 410013, China. feifan.xie@csu.edu.cn.ORCID http://orcid.org/0000-0002-9038-2676

Funding

Fundamental Research Funds for Central Universities of the Central South University 2025ZZTS0153Innovative Research Group Project of the National Natural Science Foundation of China 82474011Natural Science Foundation of Hunan Province 2023JJ40802Science Fund for Distinguished Young Scholars of Hunan Province 2023JJ40802
6 · The paper itself

Abstract

aimsAccurate determination of human intestinal effective permeability (P

methodsTwenty-seven drugs (4 acidic, 11 basic, 7 amphophilic, and 5 neutral) were included using predefined criteria. Numerical deconvolution of intravenous and oral solution data across five time windows (0.25-0.75, 0.5-1, 0.75-1.25, 1-1.5, and 1.5-2 h) was applied to estimate regional jejunal permeability. Estimates were generated under two conditions: uncorrected (P

resultsCorrelations of jejunal permeability were performed for 26 drugs (lisinopril excluded due to unreliable P

conclusionsOur oral solution-based numerical deconvolution method, accounting for first-pass metabolism, enables accurate estimation of jejunal permeability.

Indexed as

Intestinal AbsorptionJejunumAdministration, IntravenousAdministration, OralHumansModels, BiologicalPermeabilityPharmaceutical PreparationsPharmaceutical Preparationsabsorptionfirst-pass metabolismhuman intestinal effective permeabilitynumerical deconvolutionoral solution

Identifiers

PMID41735694

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.