ArticleNeuroscience bulletin2026
Distinct Role of Specialized Cutaneous Schwann Cell Network in Acute and Chronic Pain Sensation.
Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specialized cutaneous Schwann cells (scSCs) are a recently identified glial class implicated in cutaneous pain modulation, yet their three-dimensional architecture and role in chronic pain remain unclear. Using tissue optical clearing, we reconstructed the 3D morphology of scSCs, revealing an intricate mesh-like network, with extensive branching penetrating the epidermal layer and establishing close associations with A- and C-fiber primary sensory nerve terminals. Optogenetic activation of scSCs elicited nociceptive reflex behaviors, dependent on concurrent A- and C-fiber activation, but not affective-motivational responses. We further investigated the morphological and functional alterations of scSCs in chronic inflammatory pain and neuropathic pain models. Interestingly, scSCs were found to play a partial role in modulating nociceptive behaviors but not aversions in chronic pain. Together, these findings provide new insights into the functional dynamics of scSCs in nociceptive signal processing and their limited contribution to chronic pain states.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.