Evidence map›Paper›PMID 41735756›Full record

ArticleCell biochemistry and biophysics2026

Immunomodulatory Activity of Sargassum thunbergii-Derived Glucuronomannan Oligomers: G6 as a Key Bioactive Component.

Tong Hu, Min Cai, Huilan Wu, Yiwen Liao, Jing Hou, Linghua Kong, Wenjing Zhang, Yixin Bai, Jiong Wu, Junjia Liu and 2 more

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tong HuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Min CaiSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, 310023, China.
Huilan WuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Yiwen LiaoCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Jing HouCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Linghua KongCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China.
Wenjing ZhangDepartment of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Yixin BaiZhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, 310030, China.
Jiong WuZhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, 310030, China.
Junjia LiuDepartment of Tuberculosis, The Fifth People's Hospital of Suzhou, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, 215131, China.
Genxiang MaoZhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, 310030, China.
Weihua JinCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China. jinweihua@zjut.edu.cn.

Funding

Chinese Traditional Medicine Science and Technology Projects of Zhejiang Province GZY-ZJ-KJ-23041Chinese Traditional Medicine Science and Technology Projects of Zhejiang Province GZY-ZJ-KJ-24055National Natural Science Foundation of China 32402036National Natural Science Foundation of China 41906095Natural Science Foundation of Zhejiang Province LQ23C010004Natural Science Foundation of Zhejiang Province LY22D060003Suzhou Applied Basic Research Project SYW2024138
6 · The paper itself

Abstract

Cyclophosphamide (CTX) is an anticancer drug known to induce immunosuppression. This study investigated the immunomodulatory effects of Sargassum thunbergii glucuronomannan and its oligomers (Gs) in CTX-induced immunosuppressive mice. Various Gs, including G2, G4, G6, G8, and Gn, were administered to the mice. Among these, G6, G8, and Gn notably improved the spleen index, cytokine levels (IL-2, IFN-γ, NO), and antioxidant activity (SOD, GSH-Px). G6 treatment increased GSH-Px by 29.3% and promoted macrophage viability. Additionally, G6 enhanced mRNA expression of iNOS, IL-2, and TNF-α. Molecular docking analysis and dynamics analysis showed strong interactions between G6 and immune cytokines IL-2 and TNF-α, enhancing receptor-binding efficiency. These results suggested that Gs, particularly G6, played a key role in immunomodulation and might serve as potential candidates.

Indexed as

Immunologic FactorsMannansSargassumAnimalsCell SurvivalCytokinesGlucuronatesInterleukin-2MacrophagesMannoseMiceMolecular Docking SimulationNitric Oxide Synthase Type IIRAW 264.7 CellsSpleenTumor Necrosis Factor-alphaCytokinesGlucuronatesglucuronomannanImmunologic FactorsInterleukin-2MannansMannoseNitric Oxide Synthase Type IITumor Necrosis Factor-alphaCyclophosphamideDegree of polymerizationGlucuronomannan oligosaccharidesMolecular dockingSargassum thunbergii

Identifiers

PMID41735756

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.