ArticleAging cell2026
Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans.
Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The beneficial properties of CBDA in diet-induced neuroinflammation.Inflammopharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Increased life expectancy brought about by improved healthcare and lifestyle has heightened the challenge of neurodegenerative disorders like Alzheimer's disease (AD) and other age-related disorders. Neurodegeneration is known to be accompanied by loss of memory, changes in brain morphology, and neuroinflammation, and multiple factors contribute to the progression and pathogenesis of the condition. Of these factors, metabolic dysregulation is known to influence the process, but the precise mechanisms remain unexplored. In this study, we investigated the brain-specific role of the metabolic enzyme hexokinase domain-containing 1 (HKDC1) in neurodegeneration and observed that HKDC1 expression declines in humans with cognitive decline, which matches similar findings in mouse models of AD and aging. We observed age-dependent anxiety, compromised memory and learning, senescence, neuroinflammation, and mitochondrial function deficit in HKDC1-brain knockout mouse models. Furthermore, Chromatin immunoprecipitation (ChIP), RT-PCR, and Western blotting assays reveal that an age-related decline in HKDC1 expression stems from changes in chromatin conformation, which decrease the ability of transcription factor EB to regulate its transcription. These findings suggest an important role for the metabolic gene HKDC1 in the brain in relation to cognitive decline and the progression of neurodegeneration in mice and humans.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.