Evidence map›Paper›PMID 41736426›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Weimishu prescription alleviates liver-stomach disharmony and chronic gastritis by reducing inflammation and regulating gastric stem cell differentiation.

Zou Xiaoyun, Wei Minmin, Jia Shouning, Q I Yongfu, L I Hailing, Liu Yan, Shi Xiujuan, L I Junru

Abstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zou XiaoyunMedical colledge, Qinghai University, Xining 810016, China.
Wei MinminDepartment of Cardiology, Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining 810000, China.
Jia ShouningDepartment of Reserch Institute of Traditional Chinese Medicine, Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining 810000, China.
Q I YongfuDepartment of Reserch Institute of Traditional Chinese Medicine, Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining 810000, China.
L I HailingDepartment of Pharmacy, Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining 810000, China.
Liu YanMedical colledge, Qinghai University, Xining 810016, China.
Shi XiujuanMedical colledge, Qinghai University, Xining 810016, China.
L I JunruDepartment of Spleen and Stomach Diseases, Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining 810000, China.

Funding

2024 Qinghai Province "Kunlun Talents ? High-End Innovative and Entrepreneurial Talents" Top Notch Talent Project QHKLYC-GDCXCY-2024-152
6 · The paper itself

Abstract

objectiveTo investigate the therapeutic effect of Weimishu prescription (, WMSP) on chronic gastritis with liver-stomach disharmony (CG-LSD) and elucidate its molecular mechanisms involved in regulating the nuclear factor kappa-B (NF-κB) inflammatory response and gastric stem cell (GSC) differentiation.

methodsA CG-LSD rat model was established through a combined protocol involving 56% ethanol and tail-clip stimulation. Rats were administered with low-, medium-, or high-dose WMSP, the positive control drug omeprazole, or high-dose WMSP with the NF-κB agonist phorbol 12-myristate 13-acetate (PMA). Histopathological changes were assessed

resultsWMSP significantly increased rat locomotor activity, improved Traditional Chinese Medicine syndrome scores, and ameliorated pathological damage to the gastric mucosa while reducing gastric mucosal epithelial cells apoptosis. WMSP also increased the proportion of Lgr5

conclusionsWMSP ameliorated gastric mucosal injury in CG-LSD rats by regulating the NF-κB/β-catenin signaling pathway, thereby suppressing inflammation and promoting gastric stem cell differentiation. These findings highlight the therapeutic potential of WMSP, providing the foundation for further clinical evaluations of WMSP in CG-LSD treatment.

Indexed as

Cell DifferentiationDrugs, Chinese HerbalGastritisLiverStem CellsStomachAnimalsChronic DiseaseGastric MucosaHumansInflammationMaleNF-kappa BRatsRats, Sprague-DawleyDrugs, Chinese HerbalNF-kappa Bgastritisinflammationliver-stomach disharmonyNF-kappa BWeimishu prescription

Identifiers

PMID41736426
PMCPMC12884484

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.