Evidence map›Paper›PMID 41736701›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction.

Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinwei WangDepartment of Ophthalmology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.
Wen ZhouDepartment of Ophthalmology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.
Haotian XueDepartment of Ophthalmology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.
Wenjun XueSchool of Medicine, Tongji University, Shanghai, P. R. China.
Guangping GaoDepartment of Ophthalmology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.
Bing ZhuDepartment of Plastic Surgery, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.
Hongyuan SongDepartment of Ophthalmology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.
Qingqiang XuLab of Toxicology and Pharmacology, Faculty of Naval Medicine, Naval Medical University, Shanghai, P. R. China.ORCID https://orcid.org/0009-0007-6872-8865
Jing ZhaoEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, P. R. China.
Wei ShenDepartment of Ophthalmology, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0001-5754-316X

Funding

National Natural Science Foundation of China 82271106National Natural Science Foundation of China 82271119National Natural Science Foundation of China 82273672National Natural Science Foundation of China 82471116National Natural Science Foundation of China 82571241Shanghai Oriental Talents Project Youth Project ONKJ2024055Shanghai Rising-Star Program 23QA1401000
6 · The paper itself

Abstract

Hydrogels represent a transformative solution for corneal pathologies, offering the advantages of transparency, biocompatibility, and structural tunability to address the global donor tissue shortage. This review establishes a comprehensive framework for material design by delineating critical requirements, including optical clarity, mechanical anisotropy, and stable wet adhesion within dynamic ocular environments. The performances of natural, synthetic, and decellularized-matrix hydrogels are systematically compared to elucidate the structure-property relationships essential for recapitulating native corneal physiology. Beyond passive substitution, the transition toward bioactive regeneration is examined through analyses of scarless wound healing, sustained drug delivery, and stimuli-responsive implants. Furthermore, the integration of advanced technologies is evaluated with a focus on three-/four-dimensional bioprinting for hierarchical architectural reconstruction and hydrogel-based wearable bioelectronics for real-time sensing. Finally, pivotal clinical translation bottlenecks, ranging from sterilization to long-term immunocompatibility, are identified to guide the development of next-generation personalized and intelligent corneal devices.

Indexed as

CorneaHydrogelsRegenerationTissue EngineeringAnimalsBiocompatible MaterialsHumansPrinting, Three-DimensionalWound HealingBiocompatible MaterialsHydrogels3D printingartificial corneabiomaterialcorneadrug deliveryHydrogeltissue engineering

Identifiers

PMID41736701
PMCPMC13045501

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.