SynthesisFrontiers in cellular and infection microbiology2026
Association of vitamin D receptor genetic variants with therapeutic response in multidrug-resistant pulmonary tuberculosis: a systematic review.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Potential value of vitamin D as adjunctive therapy in osteoarticular tuberculosis: a comprehensive review.Infection · 2026Review
- The role of long non-coding RNA HCP5 in ulcerative cutaneous tuberculosis therapy introduction.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In high-burden nations like India, tuberculosis (TB) continues to be a significant global public health concern. HIV infection, diabetes mellitus, and low socioeconomic status are examples of comorbid illnesses that increase susceptibility to tuberculosis (TB), and the introduction of multidrug-resistant tuberculosis (MDR-TB) has made disease control even more challenging. The time-consuming nature of conventional drug susceptibility testing (DST) emphasizes the critical need for quick biomarkers to forecast treatment outcomes and resistance. Because of their possible impact on host immunity and MDR-TB risk, genetic variations particularly vitamin D receptor (VDR) polymorphisms have drawn attention. Methods: Studies published between 2000 and 2024 were the subject of an extensive examination of the literature. Relevance led to the selection of 213 articles. Keywords including vitamin D, VDR polymorphisms, MDR-TB, pulmonary tuberculosis, and immune response were used to search databases such as PubMed, Web of Science, and Google Scholar. To guarantee comprehensive coverage, both original research articles and reviews were included. Results: Low serum vitamin D levels were consistently linked to an elevated risk of MDR-TB and pulmonary tuberculosis (PTB), according to the investigation. Certain VDR polymorphisms have often been associated with altered immunological responses and an increased risk of disease, especially mutant forms like FokI and TaqI. Treatment response and disease progression have also been discovered to be influenced by immunological modulation and dietary variables. Discussion: These results imply that vitamin D levels and VDR polymorphisms could be useful biomarkers for the diagnosis and prognosis of MDR-TB. Knowing the genetic susceptibility of the host may help develop individualized treatment plans and enhance the management of MDR-TB. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261295571, identifier CRD420261295571.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.