Evidence map›Paper›PMID 41736885›Full record

ArticleMolecular therapy. Nucleic acids2026

dMMR killer: A conditional suicide gene that preferentially kills DNA mismatch repair-deficient cells.

Shinta Saito, Shingo Kato, Usaki Arai, Kensuke Tateishi, Noritaka Adachi

Abstract read
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In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shinta SaitoDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan.
Shingo KatoDepartment of Clinical Cancer Genomics, Yokohama City University Hospital, Yokohama 236-0004, Japan.
Usaki AraiDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan.
Kensuke TateishiDepartment of Neurosurgery, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, Japan.
Noritaka AdachiDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama 236-0027, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA mismatch repair (MMR) plays a crucial role in maintaining the integrity of the human genome, and impairments in this DNA repair mechanism are responsible for more than 10% of all malignant tumors. Thus, developing a strategy for stage-independent killing of MMR-deficient cells is of great significance in cancer therapy. Here, we show that transient transfection of artificial DNA constructs results in efficient killing of MMR-deficient cancer cells. These constructs were designed so that an intact suicide gene is formed and expressed in the cells, depending on a functional defect in MMR that inhibits single-strand annealing-mediated DNA recombination.

Indexed as

conditional gene expressiondMMR tumorDNA mismatch repairDT-AimmunotherapyMLH1MSH2MT: Non-coding RNAssingle-strand annealingsuicide gene

Identifiers

PMID41736885
PMCPMC12926556

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.