ReviewJournal of inflammation research2026
Vagus Nerve Regulation of Inflammatory Responses in Sepsis: Mechanistic Insights and Translational Applications.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peripheral blood levels of C-reactive protein in posttraumatic stress disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Vagus nerve as the hub in peripheral immune-inflammatory response: implications for related therapeutic drugs.Molecular biology reports · 2026Review
- Clinical utility of metagenomic next-generation sequencing in infants with severe infections.Frontiers in microbiology · 2026Article
- Neural-immune-cardiovascular axis: from mechanistic crosstalk to therapeutic targets in cardiovascular disease.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vagus nerve, often regarded as a "guardian" of physiological homeostasis, plays a pivotal role in regulating cardiovascular, neurological, and immune functions. Notably, it modulates inflammatory responses through the inflammatory reflex, a neural circuit, that involves vagal afferent sensing of peripheral inflammation and efferent regulation via the cholinergic anti-inflammatory pathway. Sepsis is a dysregulated immune disorder triggered by infection, characterized by an initial hyperinflammatory phase. In recent years, increasing attention has been directed toward harnessing vagus nerve-mediated neuromodulation to restore immune balance in sepsis. This review summarizes current insights into the mechanisms of vagus nerve-mediated inflammatory regulation, outlines two major translational strategies, and underscore the therapeutic potential of targeting vagus nerve-mediated neuroimmune pathways in sepsis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.