Evidence map›Paper›PMID 41737281›Full record

ArticleFrontiers in radiology2026

From images to physics-based computational models to digital twins: a framework for personalized cancer therapies.

Farshad Moradi Kashkooli, Wenbo Zhan, Ajay Bhandari, Tahir I Yusufaly, Michael C Kolios, Arman Rahmim, M Soltani

Abstract read
In one paragraph

Article in Frontiers in radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Farshad Moradi KashkooliDepartment of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
Wenbo ZhanSchool of Engineering, King's College, University of Aberdeen, Aberdeen, United Kingdom.
Ajay BhandariBiofluids Research Lab, Department of Mechanical Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad, India.
Tahir I YusufalyDivision of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Michael C KoliosDepartment of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
Arman RahmimDepartments of Radiology and Physics, University of British Columbia, Vancouver, BC, Canada.
M SoltaniDepartment of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we highlight recent advances in computational modeling that have significantly enhanced prospects of personalized cancer therapies by enabling insightful integration of patient-specific data, including medical images. Computational models, encompassing multi-physics and multi-scale approaches, can simulate drug transport and interactions within tissues and environments, including the tumor microenvironment, and facilitate the development of targeted diagnostic and therapeutic strategies. The incorporation of machine learning algorithms has further refined modeling, improving predictive accuracy and enabling real-time adaptive treatment planning. Although challenges remain in model validation and clinical translation, ongoing advancements are steadily bridging these gaps, bringing computational models and technologies closer to routine clinical application for the improvement of patient outcomes.

Indexed as

computational modelingdigital twinsdrug deliveryimage-based modelsmedical imagingmulti-scale and multi-physics modelsnanomedicinepersonalized medicine

Identifiers

PMID41737281
PMCPMC12926405

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.