Evidence map›Paper›PMID 41737398›Full record

ReviewFrontiers in medicine2026

Prehospital intensive blood pressure management in intracerebral hemorrhage: current evidence, controversies, and future directions.

Quan Liu, Sijia Liu, Jialin Yang, Jianfei Wang, Ling Li, Xiaoya Wu, Qing He

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Quan Liu *Emergency Department, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, China.
Sijia Liu *Emergency Department, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, China.
Jialin Yang *College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jianfei WangDepartment of Cardiovascular Medicine, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, China.
Ling LiEmergency Department, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, China.
Xiaoya WuEmergency Department, West China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital, Chengdu, China.
Qing He *Clinical Laboratory, School of Clinical Medicine, Chengdu Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous intracerebral hemorrhage (ICH) is a severe neurological emergency. Early hematoma expansion(HE), a key modifiable outcome predictor, occurs in approximately 38% of cases. This review synthesizes evidence on prehospital intensive blood pressure (BP) management. Reducing systolic BP to <140 mmHg within two hours of onset limits hematoma growth and may improve functional outcomes. However, the INTERACT-4 trial revealed risks in misdiagnosed ischemic stroke, underscoring the need for accurate prehospital subtyping. RIGHT-2 and MR ASAP trials showed no benefit and potential harm with glyceryl trinitrate (GTN). Mobile stroke units enable faster treatment but face cost and scalability barriers. Controversies persist over optimal BP targets, timing, and patient selection. Future directions include developing "Code ICH" pathways, establishing individualized BP targets, and prospectively validating precision medicine approaches.

Indexed as

blood pressureclinical translationhematoma expansionintracerebral hemorrhagemobile stroke unitprehospital

Identifiers

PMID41737398
PMCPMC12926355

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.