SynthesisFrontiers in medicine2026
Effects of vitamin D supplementation on glucose metabolism and pregnancy outcomes in GDM: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of vitamin D supplementation on glucose metabolism and pregnancy outcomes in gestational diabetes mellitus (GDM). Methods: To achieve this, we searched Chinese and English databases (PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang Med Online, and VipInfo Chinese Journal Service Platform) up to September 2024. Data were analyzed using Review Manager 5.3 and Stata 15.1, presenting continuous variables as standardized mean difference (SMD) and dichotomous variables as relative risk (RR), both with 95% confidence intervals (CI). The Cochrane tool assessed the risk of bias. Results: Twenty studies involving 1,737 patients were included. Meta-analysis showed that compared to placebo, vitamin D supplementation significantly reduced fasting glucose (SMD: -1.01, Conclusion: Vitamin D supplementation may improve glucose metabolism and reduce adverse pregnancy outcomes in GDM patients. However, the findings should be interpreted with caution due to substantial heterogeneity among studies and the methodological limitations of the included trials. These exploratory results highlight the need for further rigorous research to confirm the effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.