ArticleFrontiers in cellular neuroscience2026
Distinct cytokine-producing dendritic cell profiles in females and males with major depressive disorder.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Migraine immune cell gene targets and their relationship to psychiatric disorders.The journal of headache and pain · 2026Article
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Authors and funding
8 authors.
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Abstract
Introduction: Major depressive disorder (MDD) is a revalent and disabling condition increasingly associated with immune dysregulation. Dendritic cells (DCs) are key immune sentinels that shape inflammatory responses and T-cell polarization, including Th17 pathways implicated in depression-related mild inflammation. Given well-documented sex differences in immune responses and cytokine profiles in MDD, differential DC activation may represent a mechanistic link between sex-associated immune cell profiles in depression. However, DCs remain insufficiently characterized in MDD. Methods: We performed an exploratory study using flow cytometry-based immunophenotyping to assess circulating DC subsets, including CD1c Results: Stratification by HAM-D17 scores revealed reduced counts of pDCs and increased frequencies of CD11c Discussion: These findings demonstrate sex-specific alterations in cytokine-producing DCs in MDD and a strong association between IL-23
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