SynthesisFrontiers in pharmacology2026
Efficacy and safety of Salvia miltiorrhiza and ligustrazine injection for heart failure: a systematic review and meta-analysis.
Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Objective: To systematically evaluate the efficacy and safety of SMLI in patients with HF. Materials and methods: Eight electronic databases were systematically searched from inception up to July 2025 to identify randomized controlled trials (RCTs) comparing SMLI combined with conventional treatment versus conventional treatment alone in patients with HF. Two independent reviewers conducted study selection, data extraction, and risk of bias assessment. Meta-analysis was performed to synthesize efficacy and safety outcomes. Sensitivity analysis was conducted to verify the robustness of the findings, and publication bias was evaluated using funnel plots and Egger's test. Results: A total of 32 RCTs involving 3,077 patients were ultimately included. SMLI significantly improved LVEF (MD = 5.62, 95% CI: 4.42-6.81, Conclusion: Combining SMLI with conventional therapy enhances cardiac function and improves clinical outcomes in patients with HF. However, additional high-quality, large-scale RCTs with long-term follow-up are required to validate the long-term efficacy and safety of SMLI, given the potential limitations of the included studies. Systematic Review Registration: Identifier CRD420251114385.
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