ArticleChemical science2026
Electrochemical control enables high-concentration, one-pot macrolactonization.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
State-of-the-art macrolactone synthesis predominantly relies on the end-to-end cyclization of seco-acids, a strategy that requires high-dilution conditions (<5 mM) to suppress oligomerization. To address this limitation, we report an electrochemical macrolactonization protocol that operates at a significantly higher concentration (50 mM). Leveraging an iodide/PPh
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