Evidence map›Paper›PMID 41737719›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Neuropsychiatric symptoms relate to everyday functioning as reported by cognitively unimpaired older adults and their study partners.

Grace J Ma, Mark A Dubbelman, Catherine E Munro, Onyinye J Udeogu, Madeline Yu, Claudia Aibel, Rebecca E Amariglio, Patrizia Vannini, Gad A Marshall, Jennifer R Gatchel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Grace J MaDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-4005-4391
Mark A DubbelmanCenter for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Catherine E MunroCenter for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Onyinye J UdeoguDepartment of Neurology Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Madeline YuDepartment of Neurology Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Claudia AibelDepartment of Neurology Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Rebecca E AmariglioCenter for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Patrizia VanniniCenter for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Gad A MarshallCenter for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Jennifer R GatchelDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeuropsychiatric symptoms and changes in everyday functioning emerge early in Alzheimer's disease, but the relationships among these signs are rarely considered. We aimed to examine associations between neuropsychiatric symptoms and daily functioning in cognitively unimpaired older adults.

methods178 participants (70.4 ± 6.1 years; 62% female) and their study partners completed the Mild Behavioral Impairment Checklist (MBI-C) and Alzheimer's Disease Cooperative Study Activities of Daily Living Prevention Instrument (ADCS ADL-PI). We investigated associations between self- and study partner-reported MBI-C and ADCS ADL-PI.

resultsHigher study partner-reported MBI-C scores were associated with lower participant-reported (estimate [ DISCUSSION: Neuropsychiatric symptoms relate to daily functioning in cognitively unimpaired older adults. Early detection and management of these symptoms may improve the quality of life and sensitivity of clinical trial outcomes. Highlights: Neuropsychiatric symptoms relate to worse daily function in unimpaired older adults.Difficulties with motivation and emotional regulation were the strongest predictors.Associations were seen with both self-reported and study partner-reported measures.

Indexed as

everyday functioningfunctioninstrumental activities of daily livingneuropsychiatric symptomspreclinical

Identifiers

PMID41737719
PMCPMC12927927

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.