ArticlePain research & management2026
Exploring the Causal Relationship Between Inflammatory Cytokines and Joint Pain: A Mendelian Randomization Study.
Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Exploring the Causal Relationship Between Inflammatory Cytokines and Joint Pain: A Mendelian Randomization Study.Pain research & management · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Joint pain is a major cause of chronic disability worldwide, with complex mechanisms and limited treatment options. Inflammatory cytokines have been implicated in the pathogenesis of joint pain; however, their causal roles remain unclear. This study employed Mendelian randomization (MR) to explore the causal relationships between 41 inflammatory cytokines and the risk of joint pain. Methods: We integrated genome-wide association study (GWAS) summary statistics from European-ancestry populations, including data on joint pain (1451 cases and 461,559 controls) and inflammatory cytokine levels (8293 Finnish participants). Genetic variants meeting instrumental variable assumptions ( Results: Cutaneous T-cell attracting chemokine (CTACK)/CCL27 (OR: 0.998 and 95% CI: 0.996-0.999) and interleukin-2 receptor Conclusion: This study identifies IL-18, CTACK, and IL-2RA as potential causal mediators of joint pain, providing genetic evidence that informs future precision approaches to analgesia. Future research should validate these findings across diverse populations and elucidate the molecular mechanisms underlying them to advance targeted therapies.
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