Evidence map›Paper›PMID 41738141›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis.

Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yanting HouMedical College of Shihezi University, Shihezi, China.
Yinghua MaMedical College of Shihezi University, Shihezi, China.
Qin LiuMedical College of Shihezi University, Shihezi, China.
Dingling MaMedical College of Shihezi University, Shihezi, China.
Yuxin TongMedical College of Shihezi University, Shihezi, China.
Lili XuMedical College of Shihezi University, Shihezi, China.
Xiaolong ChuMedical College of Shihezi University, Shihezi, China.
Jingzhou WangMedical College of Shihezi University, Shihezi, China.
Maodi LiangMedical College of Shihezi University, Shihezi, China.
Mengyuan ZhaoMedical College of Shihezi University, Shihezi, China.
Huizi ZhangMedical College of Shihezi University, Shihezi, China.
Yurui SuMedical College of Shihezi University, Shihezi, China.
Jianxin XieMedical College of Shihezi University, Shihezi, China.
Cuizhe WangMedical College of Shihezi University, Shihezi, China.
Jun ZhangMedical College of Shihezi University, Shihezi, China.ORCID https://orcid.org/0000-0001-9796-994X

Funding

Natural Science Foundation of China 82160156Natural Science Foundation of China 82160496Natural Science Foundation of China 82260162Scientific and Technological Research Project of Xinjiang Production and Construction Corps 2022AB022Scientific and Technological Research Project of Xinjiang Production and Construction Corps 2022ZD001Scientific and Technological Research Project of Xinjiang Production and Construction Corps 2022ZD083Scientific and Technological Research Project of Xinjiang Production and Construction Corps 2023AB057Scientific and Technological Research Project of Xinjiang Production and Construction Corps 2023ZD037Tianshan Talent Project in Xinjiang Autonomous Region of China 2023TSYCCX0116Tianshan Talent Project in Xinjiang Autonomous Region of China 2023TSYCQNTJ0032
6 · The paper itself

Abstract

Circulating odd-chain fatty acids (OCFAs), such as pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0), inversely associate with metabolic syndrome-related type 2 diabetes mellitus (T2DM), cardiovascular disease, and all-cause mortality. However, the physiological function of nonadecanoic acid (C19:0) remains unclear. In this study, we identify an inverse association between plasma C19:0 levels and T2DM in the Kazakh population in Xinjiang, China. Investigations using diet-induced obese (DIO) and db/db mouse models revealed that C19:0 has the potential to improve glucose tolerance and enhance insulin sensitivity. Mechanistically, our data demonstrate that C19:0 acts as an endogenous ligand for GPR120, mediating metabolic benefits both in vitro and in vivo. Further analyses indicate that 2-hydroxyacyl-CoA lyase (HACL1) directly participates in the biosynthesis of C19:0, with its expression regulated by peroxisome proliferator-activated receptor α (PPARα). Elevated palmitic acid (PA) levels in obesity suppress PPARα via miR548ab release, thereby impairing the PPARα-HACL1-C19:0 signaling pathway. Collectively, these findings establish a novel association between C19:0 and T2DM and elucidate a distinct mechanism accounting for reduced circulating C19:0 levels in obesity.

Indexed as

Diabetes Mellitus, Type 2Fatty AcidsGlucoseHomeostasisObesityAnimalsChinaDisease Models, AnimalHumansInsulin ResistanceMaleMicePPAR alphaFatty AcidsGlucosePPAR alpha

Identifiers

PMID41738141
PMCPMC13159108

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.