Observational studyImmunity, inflammation and disease2026
Clinico-Epidemiological and Molecular Evidences for Reactivation of Herpesviruses in Dapsone-Induced Hypersensitivity Reactions in Nepalese Leprosy Patients: An Observational Study.
Observational study in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the risk of dapsone hypersensitivity syndrome in Nepalese Leprosy Patients via HLA-B* 13:01 screening using real-time PCR and comparative meta-analysis of international data.PLoS neglected tropical diseases · 2026Pooled it
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDapsone hypersensitivity (DHS) is a potentially fatal and severe cutaneous adverse reaction that occurs in patients taking dapsone. As leprosy, for which dapsone is used as part of multidrug therapy, usually occurs in countries with resource limitations, the morbidity and mortality caused by DHS are more dreadful. Herpesviruses (especially HHV-5 and 6) are frequently associated with the etiology of drug-induced hypersensitivity reactions, and the reactivation of these viruses coincides with the reflare of clinical symptoms even after the cessation of culprit drugs.
methodsWe reviewed the hospital charts of patients (Cohort 1) with DHS who were admitted to our hospital at the time of the DHS episode. Similarly, we examined the presence of HHV-5 and 6 in another independent group of DHS blood samples (Cohort 2) by PCR.
resultsSeventy-one percent (71%, 17/24) of DHS patients experienced recrudescence (reflare) of symptoms ~20 days after cessation of dapsone in Cohort 1. In Cohort 2, 39% (13/33) of blood samples from DHS patients showed the presence of at least one herpesvirus.
conclusionIn this exploratory study, our data suggest the role of herpesviruses in the natural history of DHS and identify patterns that support future hypothesis-driven investigations into antiviral treatment strategies for the management of DHS cases, with the potential to reduce morbidity and mortality.
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