Evidence map›Paper›PMID 41738400›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease.

Seyyed Ali Hosseini, Etienne Aumont, Nesrine Rahmouni, Marcel S Woo, Arthur C Macedo, Brandon Hall, Tevy Chan, Joseph Therriault, Lydia Trudel, Yansheng Zheng and 35 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Seyyed Ali HosseiniTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Etienne AumontTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Nesrine RahmouniTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Marcel S WooTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Arthur C MacedoTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Brandon HallTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Tevy ChanTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Joseph TherriaultTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Lydia TrudelTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Yansheng ZhengTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Gleb BezginTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Aurélie LebrunTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Jaime Fernandez AriasTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Kely Quispialaya SocualayaTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Cécile TissotLawrence Berkeley National Laboratory, Berkeley, California, USA.
Stijn ServaesTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Yi-Ting WangTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Delphine Oliva-LopezTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Stuart MitchellTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Robert HopewellTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Chris Hung-Hsin HsiaoDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Catherine SalehDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Jenna StevensonThe McGill University Research Center for Studies in Aging, Douglas Mental Health Institute, Montreal, Quebec, Canada.
Firoza LussierDepartment Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Liyong WuTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Min ChuTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Sanjeev ChawlaDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Vladimir FonovDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Gassan MassarwehDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Yasser Iturria MedinaDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Jean-Paul SoucyDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Karine ProvostDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
David A RudkoDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Thomas KarikariDepartment Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andréa Lessa BenedetDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Maxime MontembeaultThe McGill University Research Center for Studies in Aging, Douglas Mental Health Institute, Montreal, Quebec, Canada.
Paolo VitaliDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Serge GauthierDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
D Louis CollinsDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Jesse KlostranecDepartment of Diagnostic and Interventional Neuroradiology, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Tharick A PascoalDepartment Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0001-9116-1376

Funding

Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
and Swedish State Support for Clinical Research #ALFGBG-71320Brain Canada Foundation 33397Brain Canada Foundation CFI Project 34874Canadian Consortium of Neurodegeneration and Aging (CCNA MOP-11-51-31 -team 1NIA NIH HHS R01 AG083874the Alzheimer's Association NIRG-12-92090the Alzheimer's Association NIRP-12-259245the Corona Foundation and the Else-Kröner-Fresenius Foundation 2023_EKMS.03the European Union's Horizon Europe research and innovation programme 101053962the Fonds de Recherche du Québec-Santé (FRQS; Chercheur Boursier 2020-VICO-279314the Fonds de Recherche du Québec-Santé (FRQS; Chercheur Boursier 2024-VICO-356138the Swedish Research Council #2019-02397the Swedish Research Council #2022-01018the Swedish Research Council #2023-00356the Weston Brain Institute, Canadian Institutes of Health Research (CIHR) 159815the Weston Brain Institute, Canadian Institutes of Health Research (CIHR) 162303the Weston Brain Institute, Canadian Institutes of Health Research (CIHR) MOP-11-51-31the Weston Brain Institute, Canadian Institutes of Health Research (CIHR) RFN 152985
6 · The paper itself

Abstract

introductionEnlargement of the choroidal-ventricular system occurs in aging and Alzheimer's disease (AD), but emerging evidence links these abnormalities to amyloid beta (Aβ) aggregation. We tested this hypothesis by assessing associations between AD pathophysiology and choroidal-ventricular system measures across the AD continuum.

methodsVentricular volume, choroid-plexus volume, and ventricular radioactivity after positron emission tomography (PET) tracer injections were analyzed in 385 Translational Biomarkers in Aging and Dementia (TRIAD) and 282 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants using linear models and partial correlations. A composite score combining these measures was also tested against established AD biomarkers.

resultsWith advancing AD stages, ventricular and choroid-plexus volumes increased while ventricular radioactivity declined. These measures were interrelated, and abnormalities appeared even in amyloid-negative elderly. Across cohorts, they correlated with amyloid- and tau-PET, cerebrospinal fluid (CSF) and plasma p-tau isoforms, glial fibrillary acidic protein (GFAP), and cognition. Voxel-wise analyses showed strong associations with cortical Aβ, mediating downstream tau effects. DISCUSSION: Changes in the choroidal-ventricular system are mutually correlated and carry an additive-effect on cortical Aβ load.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCerebral VentriclesChoroid PlexusAgedAged, 80 and overAgingBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansMalePositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkersGlial Fibrillary Acidic Proteintau ProteinsAlzheimer diseaseamyloid‐betabiomarkersbrain ventriclescerebrospinal fluidchoroid plexuscognition disordersglial fibrillary acidic proteinneurodegenerative diseasespositron‐emission tomographytau proteins

Identifiers

PMID41738400
PMCPMC12933412

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.