Evidence map›Paper›PMID 41738687›Full record

ArticleJournal of the International Neuropsychological Society : JINS2026

Factors associated with subjective cognitive complaints in former American football players.

Jennifer S Adler, Monica T Ly, Eukyung Yhang, Yorghos Tripodis, Charles H Adler, Laura J Balcer, Charles Bernick, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Jennifer S Adler *VA San Diego Healthcare Systemhttps://ror.org/00znqwq11, USA.ORCID https://orcid.org/0009-0006-6546-5804
Monica T Ly *Boston University Alzheimer's Disease Research Center, USA.
Eukyung YhangDepartment of Biostatistics, Boston University School of Public Health, USA.
Yorghos TripodisDepartment of Biostatistics, Boston University School of Public Health, USA.
Charles H AdlerNeurology, Mayo Clinic School of Medicine - Scottsdale Campus, USA.
Laura J BalcerNYU Grossman School of Medicine, USA.
Charles BernickCleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, USA.
Nicholas AshtonTranslational Genomics Research Institute, Banner Alzheimer's Institute, USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Sweden.
Kaj BlennowNeurochemistry, Neuroscience and Physiology, Sweden.
Elaine PeskindVA Northwest Mental Illness Research, Education, and Clinical Center, USA.
Sarah J BanksPsychiatry, University of California San Diego Health Scienceshttps://ror.org/0168r3w48, USA.
William B BarrNeurology, NYU Grossman School of Medicine, USA.
Jennifer V WethePsychiatry and Psychology, Mayo Clinic School of Medicine - Scottsdale Campus, USA.
Mark W BondiVA San Diego Healthcare Systemhttps://ror.org/00znqwq11, USA.
Lisa Delano-WoodVA San Diego Healthcare Systemhttps://ror.org/00znqwq11, USA.
Robert C CantuBoston University, USA.
Michael J ColemanDepartment of Psychiatry, Brigham and Women's Hospital, USA.
David W DodickNeurology, Mayo Clinic School of Medicine - Scottsdale Campus, USA.
Daniel H DaneshvarDepartment of Neurology, Mayo Clinic Alix School of Medicine Arizona Campus, USA.
Michael D McCleanBoston University School of Public Health, USA.
Jesse MezBoston University Alzheimer's Disease Research Center, USA.
Joseph N PalmisanoBoston University School of Public Health, USA.
Brett MartinBoston University School of Public Health, USA.
Alexander P LinDepartment of Psychiatry, Brigham and Women's Hospital, USA.
Inga K KoerteDepartment of Psychiatry, Brigham and Women's Hospital, USA.
Sylvain BouixDepartment of Psychiatry, Brigham and Women's Hospital, USA.
Jeffrey L CummingsUniversity of Nevada Las Vegas, USA.
Martha E ShentonPsychiatry & Radiology, Brigham & Women's Hospital, Harvard Medical School, USA.
Eric M ReimanTranslational Genomics Research Institute, Banner Alzheimer's Institute, USA.
Robert A SternBoston University Alzheimer's Disease Research Center, USA.
Michael L AloscoBoston University Alzheimer's Disease Research Center, USA.ORCID https://orcid.org/0000-0002-8113-8428
DIAGNOSE CTE Research Project

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSubjective cognitive complaints (SCC) can precede cognitive decline and are associated with demographic, exposure, lifestyle, and psychological factors. Prevalences of SCC and their correlates in individuals with repetitive head impacts (RHI) are poorly understood. This study characterized SCC in former elite American football players by frequency, mood and behavioral correlates, concordance with informant reports, and associations with neuropsychological test performance, cerebrospinal fluid (CSF), and magnetic resonance imaging (MRI) markers of neurodegeneration.

methodFormer American football players (

resultsRates of SCC ranged from 43 to 77% depending on the domain. Symptoms of depression, impulsivity, and anxiety were strongly associated with SCC. Self- and informant-reported SCC showed moderate inter-rater agreement. Adjusting for age, race, education,

conclusionsSCC are strongly associated with neuropsychiatric factors in former American football players. SCC may also be a marker of cognitive decline and neurodegeneration.

Indexed as

Brain ConcussionCognition DisordersCognitive DysfunctionFootballAgedAmyloid beta-PeptidesCerebral CortexExecutive FunctionHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedNeurofilament ProteinsNeuropsychological TestsPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)MAPT protein, humanneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer’s diseasecerebrospinal fluidchronic traumatic encephalopathycognitionneuropsychological testingrepetitive head impact

Identifiers

PMID41738687
PMCPMC12957654

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.