ArticlemSphere2026
The etiology of exudative cutaneous ulcers in a yaws-endemic community prior to receipt of antimicrobials is similar to that found in communities after mass treatment with azithromycin.
Julie A Brothwell, Evelyn Toh, Yue Xing, Qunfeng Dong, Linda H Xu, Lorenzo Giacani, Camila G Beiras, Oriol Mitjà, Xiang Gao, Stanley M Spinola
Abstract read
In one paragraphArticle in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Julie A Brothwell *Department of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0002-5277-3692 Evelyn Toh *Department of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0003-2932-4060 Yue Xing *Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Qunfeng DongDepartment of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Linda H XuDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Lorenzo GiacaniDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Camila G BeirasSkin Neglected Tropical Diseases and Sexually Transmitted Infections Section, Fight Infections Foundation, University Hospital Germans Trias i Pujol, Badalona, Spain.
Oriol MitjàSkin Neglected Tropical Diseases and Sexually Transmitted Infections Section, Fight Infections Foundation, University Hospital Germans Trias i Pujol, Badalona, Spain.
Xiang GaoDepartment of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.ORCID 0000-0002-1864-837X Stanley M SpinolaDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0003-3435-9911 Funding
H2020 European Research Council ERC-2019-STG 850450National Institute of Allergy and Infectious Diseases R01AI134727
6 · The paper itselfAbstract
Mass drug administration (MDA) of azithromycin (AZ) and case finding and treatment of children with cutaneous ulcers (CUs) have been trialed as strategies to eliminate yaws. Metagenomic sequencing of CU swabs obtained from children 3 to 4 years after the initiation of a yaws elimination campaign on Lihir Island showed enrichment for
Indexed as
Anti-Bacterial AgentsAzithromycinMass Drug AdministrationSkin UlcerYawsChild, PreschoolEndemic DiseasesFemaleHaemophilus ducreyiHumansMaleMetagenomicsStreptococcus pyogenesTreponemaTreponema pallidumAnti-Bacterial AgentsAzithromycinArcanobacterium haemolyticumcutaneous ulcersHaemophilus ducreyiStreptococcus pyogenesTreponema pallidum subsp. pertenueyaws
Identifiers
PMID41738753
PMCPMC13037408
What Socratic holds
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